Scientists identify the neuroblastoma cells that signal poor outcomes
Single-cell RNA sequencing and spatial omics reveal distinct neuroblastoma cell populations, identifying gene expression markers associated with treatment resistance and poor outcomes in pediatric cancer...
Urine test may improve bladder cancer diagnosis and guide treatment decisions
Researchers developed a urine test that detects bladder cancer, predicts which patients will benefit from immunotherapy versus chemotherapy, and can confirm whether treatment worked. simple urine test devised by researchers at Stanford Medicine and the VA Palo Alto Health ...
Tracing 700 million years of cell evolution
A new AI tool helps identify hidden similarities across distant species. Why do traditional genetic tools struggle to compare distant species? Scientists often compare cells using single-cell RNA sequencing, which shows which genes are active in each cell. When ...
RNA-Seq reveals a new way the developing heart controls its growth
Findings may ultimately have implications for heart repair after a heart attack Northwestern Medicine scientists have uncovered an unexpected part of the answer: lymphatic vessels, long known for transporting fluid and immune cells, also send signals to different cardiac ...
The Human RNome Project Consortium seeks to publish first-ever complete sequence of the body’s RNA
Brown professor Vivian Cheung is one of the founding members of the consortium. The Human Genome Project was a 13-year effort to generate the first ever complete sequence of all human DNA, widely regarded as one of science’s greatest ...
Unmasking “zombie cells” in aging tissue with an AI-powered barcode
Tracking down senescent cells, which accumulate as we age, could help diagnose age-related disorders and guide researchers working on new treatments. As we age, some of the cells in our body enter a state of senescence, in which they ...
RNA variant imaging for cancer diagnosis
RNA Variant Imaging is attracting attention because it addresses a persistent blind spot in cancer diagnostics: many clinically relevant RNA isoforms, splice events, and fusion transcripts are hard to interpret from DNA data alone. Recent work from 2024 to ...
Autism-risk mutations reveal two opposing patterns of brain gene activity
Analysis of more than 1,000 mouse brain transcriptomes identifies shared molecular patterns that vary with sex and respond differently to experimental drug exposure Autism spectrum disorder (ASD) is associated with more than 1,200 risk genes, raising a fundamental question: ...
Avoiding a sticky situation: how cells stop messenger RNAs from clumping together
Messenger RNA, or mRNA, is best known for carrying genetic instructions from DNA to the cellular machinery that makes proteins. But all RNA molecules have another, less appreciated property: they are naturally sticky. When RNA is removed from cells ...
RNA Sequencing identifies new tick-borne virus that causes flu-like illness
Scientists in China have identified a novel tick-borne virus that causes an influenza-like illness characterized by fever, fatigue, gastrointestinal (GI) symptoms, and abnormal lab findings. The team, led by researchers from the State Key Laboratory of Pathogen and Biosecurity ...














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