Worm’s radical transformation shows metamorphosis can change the functions of cells
A squishy worm that starts its life as something of a floating head in the Pacific Ocean is changing what scientists know about metamorphosis at the cellular level.Unlike humans, about 80% of animal species undergo metamorphosis, a stepped development ...
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Direct RNA sequencing revealed thousands of chimeric mRNAs in mammalian cells, uncovering previously unknown proteins with roles in immunity, inflammation, and potential drug discovery...
Atlas of the brain’s striatum could guide researchers to new drug treatments
A new study reveals insights into populations of neurons affected by Huntington’s disease, schizophrenia, addiction, and other disorders. A region of the brain called the striatum is critical for many cognitive and motor functions, including decision-making, control of movement, ...
Immune cells offer insights on billion-dollar virus
Whiteleg shrimp studies examine key organs and pinpoint genes linked to virus response. Studies have shed light on a disease that has caused billion-dollar losses in a key commercial seafood species. Insights into the immune system of the Pacific whiteleg shrimp, ...
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Aging is a major risk factor for chronic diseases, and calorie restriction (CR) is a robust non-pharmacological intervention that can extend health span in multiple species. Alternative splicing (AS) generates multiple RNA isoforms from a single pre-mRNA and becomes ...
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
A new study published in Engineering uses single-cell RNA sequencing (scRNA-seq) to unpack how phytosterol oxidation products (POPs), common dietary lipid derivatives, alter vascular cell heterogeneity and drive atherosclerosis (AS) through defined inflammatory signaling pathways. Atherosclerosis is a chronic inflammatory cardiovascular ...
Unlocking the past – new method helps gain insights into old tissue
A book sits atop a table. Although it’s closed, its title, “Encyclopedia of Human Tissue,” promises untold secrets. Perhaps with this book, you can learn about different cell types and what they look like under normal conditions or conditions ...
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Researchers have developed a novel AI model that can analyze a routine whole histopathology image and simultaneously predict cancer subtype, specific genetic mutations, and survival outcomes across 32 different solid cancers rather than focusing on a single cancer type. ...
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
The study was led by first author Hai Duc Nguyen from the Division of Microbiology, Tulane National Biomedical Research Center, Tulane University. The corresponding author is Woong-Ki Kim, who is affiliated with the Division of Microbiology, Tulane National Biomedical Research ...
RNA sequencing helps predict stem cell transplant benefit in pediatric AML
Pediatric acute myeloid leukemia (AML) is a severe hematological malignancy where allogeneic hematopoietic stem cell transplantation (allo-HSCT) serves as a critical, life-saving intervention. However, selecting the appropriate candidates for this intensive procedure remains a clinical challenge. Current clinical decision-making ...
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