A clinical research team leads the discovery of applying amniotic fluid cells obtained during 16-24 weeks of pregnancy as a novel sample type for RNA-sequencing in prenatal diagnosis to help more families with tailored clinical management. It is the first...
Read More »tRNA-MaP – functional analyses of RNA-related enzymes using a next-generation DNA sequencer
tRNA-MaP can rapidly analyze the specificity of tRNA m1A22 methyltransferase (TrmK) for substrate tRNAs Genetic information encoded in genomic...
Read More »hECA – A human Ensemble Cell Atlas using data collected from scattered public datasets
Imagine a virtual human body, rich in complexity and detail, that enables scientists to simulate experiments that can’t be conducted in vivo or...
Read More »CHOP and NJIT researchers develop new tool for studying multiple characteristics of a single cell
Researchers from Children’s Hospital of Philadelphia (CHOP) and New Jersey Institute of Technology (NJIT) developed new software that integrates a variety of information from a single cell, allowing...
Read More »Single-nucleus RNA-sequencing and spatial transcriptomics profiling reveal how cancer cells evade targeted therapy
UCSF researchers identify the cellular source of recurrent glioma. they found that phenotype switching, as opposed to genetic evolution, may be the escape mechanism that explains the failure of...
Read More »Spatial transcriptomics sharpens distinctions between brains
Single-cell RNA sequencing is becoming a workhorse of transcriptomics, giving researchers details on transcription in individual cells and a sense of both tissue-level heterogeneity and how many cell types...
Read More »The challenges and opportunities of scRNA-seq in COVID-19 research and clinical translation
The application of single-cell RNA sequencing in COVID-19 research has greatly improved our understanding of COVID-19 pathogenesis and immunological characteristics. In this commentary, researchers from the University of Texas Health Science Center at Houston discuss the current challenges, limitations, and ...
Read More »Single-cell study brings prostate tumors into focus and highlights potential treatment target
Treatments targeting the androgen receptor have extended the lives of people with advanced prostate cancer. At first, prostate cancers need androgens...
Read More »Meta-analysis reveals how crowds may change gene expression in some insects
Scientists investigate how genes in some insects can influence one another to change their expression depending on environmental conditions...
Read More »Mount Sinai researchers present a comprehensive, single-nucleus RNA sequencing atlas of late prenatal human development
Late prenatal development of the human neocortex encompasses a critical period of cortical expansion and glial development (cells that are essential to the central nervous system), which is poorly understood...
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