In the fast-paced field of single-cell biology, studies that compare methods can help scientists to pick the right technique for their research. Single-cell biology has exploded over the past decade. Between 2015 and 2021, studies in the PubMed database of ...
Read More »Impact of the Human Cell Atlas on medicine
Single-cell atlases promise to provide a ‘missing link’ between genes, diseases and therapies. By identifying the specific cell types, states, programs and contexts where disease-implicated genes act...
Read More »RNA-Seq links severe COVID-19 with molecular signatures of brain aging
Although COVID-19 is primarily a respiratory disease, neurological symptoms have been described in many COVID-19 patients, including in recovered...
Read More »Transcriptomic technique may help identify infections after knee and hip replacement
Periprosthetic joint infection (PJI) is a devastating complication of knee and hip replacement surgery that can, in some cases, be difficult to distinguish...
Read More »The mystery of the origins of introns solved
UCSC scientists point to introners as the source of the vast majority of introns, a source of molecular complexity unique to eukaryotes One of the most long-standing, fundamental mysteries of biology surrounds the poorly understood origins of introns. Introns are ...
Read More »Transcriptional recording method, Record-seq wins Young Scientist grand prize
For his work in developing Record-seq, a breakthrough technology that records the activities of microbiota in the gut noninvasively and furthers the understanding of gastrointestinal health, Florian Schmidt is the grand prize winner of the 2022...
Read More »Researchers established a framework to streamline single-cell RNA-seq analysis of the heterogeneous tumor microenvironment
With development of many effective approaches to fighting cancer, the focus becomes less about finding new ways to treat patients and more about identifying which already available treatments a patient will respond best to. Immune checkpoint inhibitors have...
Read More »Researchers use RNA-Seq to discover behavior of immunity genes leading to worse COVID outcomes for men
Why do men have worse outcomes than women from COVID-19? A new study suggests it’s not something wrong with males, it’s something right with females. Specifically, females’ innate immune...
Read More »New statistical method improves RNA-Seq analyses
A new statistical method provides a more efficient way to uncover biologically meaningful changes in genomic data that span multiple conditions — such as cell types or tissues. Whole genome studies...
Read More »RNA sequencing unlocks pattern of gene activity for ADHD
New study uses postmortem brain tissues to understand genomic differences in individuals with attention deficit hyperactivity disorder. Researchers at the National Institutes of Health have...
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