Commentary

A defining decade in DNA (and RNA) sequencing

rna-seq

from Nature Methods The past decade has seen a transformation, fueled by the availability of NGS platforms, in applications based on generating DNA and RNA sequence. There are more than 50 multiletter-acronym or ‘MLA-seq’ applications for interrogating a wide variety ...

Read More »

Harvard researchers among the first to receive grant funding through BRAIN Initiative

rna-seq

from the Harvard Gazette by Peter Reuell, Harvard Staff Writer Two groups of Harvard scientists will be among the first researchers nationwide to receive grant funding through the BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative launched last year by ...

Read More »

Scientists discover how disruptive genetic RNA is made

rna-seq

Israeli-led research finds circular RNA puts brakes on gene expression, could cause degenerative disease from Times of Israeli by Andrew Tobin An Israeli-led research team has discovered how a mysterious circular type of genetic molecule is produced, and that might ...

Read More »

Multiple Studies Cite Progress toward Quality Transcriptomes

rna-seq

from Genetic Engineering News RNA sequencing (RNA-seq), a means of depicting the transcriptome, is being used with increasing frequency to characterize a growing array of conditions—everything from prenatal birth defects to disorders of the elderly. Yet the technique, which is ...

Read More »

Bringing RNA-Seq closer to the clinic

rna-seq

Several multicenter benchmark data sets represent valuable steps toward using RNA-seq as a diagnostic tool with clinical utility. RNAs are excellent candidates for monitoring and diagnosing disease. In recent years, high-throughput RNA sequencing (RNA-seq) has opened new possibilities for determining ...

Read More »

RNA sequence could help doctors to tailor unique prostate cancer treatment programs

rna-seq

from Medical Xpress Sequencing RNA, not just DNA, could help doctors predict how prostate cancer tumors will respond to treatment, according to research published in the open access journal Genome Biology. Because a tumor’s RNA shows the real time changes ...

Read More »

Establishing Clinical-Grade RNA Sequencing

from Weill Cornell Medical College News The many different approaches used to sequence RNA, even severely degraded RNA, can produce relatively similar results, a finding that should reassure patients, physicians and scientists faced with a variety of new technologies that ...

Read More »

Next-generation sequencing turns 10!

rna-seq

Ten years ago next-generation sequencing (NGS) technologies appeared on the market. During the past decade, tremendous progress has been made in terms of speed, read length, and throughput, along with a sharp reduction in per-base cost. Together, these advances democratized ...

Read More »

Intracellular RNA-Seq

rna-seq

from Genetic Engineering News by Anton Simeonov, Ph.D. This literature review highlights a study led by George Church describing FISSEQ, or fluorescent in situ RNA sequencing. Methods such as fluorescence in situ hybridization (FISH) allow gene expression to be observed ...

Read More »