Commentary

Microarray Not Fade Away

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Yes, many are attracted to next-generation sequencing, but loyalty to chip-based phenotyping has its rewards, particularly in screens of large sample sets. from Genetic Engineering News – by Lisa Heiden The microarray, the legacy technology for measuring gene expression, will ...

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Genetic Data Clarify Insect Evolution

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from The Scientist by Kate Yandell Researchers create a phylogenetic tree of insects by comparing the sequences of 1,478 protein-coding genes among species. The study authors, who are part of an international consortium working on the 1K Insect Transcriptome Evolution ...

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The New World of Isoform Sequencing

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from Genetic Engineering News by Jonas Korlach Long-Read Sequencing Can Offer the Most Comprehensive View Yet of Gene Activity Not too long ago, the life sciences community was still debating whether sequencers would ever overtake microarrays as the preferred means ...

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How deep is enough in single-cell RNA-seq?

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Guidelines for determining sequencing depth facilitate transcriptome profiling of single cells in heterogeneous populations. In recent years, single-cell RNA-seq has emerged as a powerful, new approach for characterizing the cell types present in a mixed population. These studies usually involve ...

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Gene expression patterns revealed in pancreatic circulation tumor cells

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from Oncology Nurse Advisor by Kathy Boltz, PhD Analysis of circulating tumor cells (CTCs) in a mouse model of pancreatic cancer identified distinct patterns of gene expression in several groups of CTCs, including significant differences from the primary tumor that ...

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A defining decade in DNA (and RNA) sequencing

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from Nature Methods The past decade has seen a transformation, fueled by the availability of NGS platforms, in applications based on generating DNA and RNA sequence. There are more than 50 multiletter-acronym or ‘MLA-seq’ applications for interrogating a wide variety ...

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Harvard researchers among the first to receive grant funding through BRAIN Initiative

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from the Harvard Gazette by Peter Reuell, Harvard Staff Writer Two groups of Harvard scientists will be among the first researchers nationwide to receive grant funding through the BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative launched last year by ...

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Scientists discover how disruptive genetic RNA is made

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Israeli-led research finds circular RNA puts brakes on gene expression, could cause degenerative disease from Times of Israeli by Andrew Tobin An Israeli-led research team has discovered how a mysterious circular type of genetic molecule is produced, and that might ...

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