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Just as RNA itself has primary and secondary structure, RNA-Seq analysis has primary, Secondary and even tertiary steps. Which is the right tool at...

To Our Readers, Thanks so much for your patience with our recent downtime! The RNA-Seq Blog was attacked by a malicious hacker last Friday. Both our host and developer have been working...

Multimodal analysis enables the simultaneous measurement of multiple modalities or the integration of data from multiple experiments. For a long time now, the advantages of sequencing mRNA (scRNA – Seq) in individual cells, to understand...

Both poly(A) enrichment and ribosomal RNA depletion are commonly used for RNA sequencing. Either has its advantages and disadvantages that may lead to biases in the downstream analyses...

Ribonucleic Acid (RNA) is the major macromolecule essential for converting genetic codes into proteins through structures called ribosomes for performing cellular functions. The major types of RNA are Transfer RNA (tRNA), Messenger RNA (mRNA), and Ribosomal RNA (rRNA). It can ...

By definition, a transcriptome is the entire collection of messenger Ribonucleic Acid molecules contained in a specific cell or tissue type in an organism. It correlates with the range of RNA being transcribed from a genome under investigation at a ...

The technology of Single-cell RNA sequencing (scRNA-Seq) has enabled robust as well as simple access to the transcriptomes of the single cells. With Single Cell RNA-Seq, getting better insights about the individual cell tissues has become a lot easier. This, ...

SARS-CoV-2 genotyping has been instrumental to monitor virus evolution and transmission during the pandemic. The reliability of the information extracted from the genotyping efforts depends on a number...

The goal of the HMS Initiative for RNA Medicine is to make and translate RNA discoveries into novel therapeutics and diagnostics by fostering a climate of outstanding basic, translational and clinical research with world-leading scientists and...

Gene expression quantification is a fundamental computational inference problem at the intersection of genomics, machine learning, and biology. The expression levels (abundances) of genes and transcripts...