Advancing Transcriptomics: An Insights into Lung Cancer The Treatment Paradigm for Lung Cancer Faces New Revolution Next Generation Sequencing (NGS) is not just a standalone tool but part of a larger narrative. Originally designed to get over the Sanger sequencing ...
Read More »3′ RNA-seq is superior to standard RNA-seq in cases of sparse data
The application of RNA-sequencing has led to numerous breakthroughs related to investigating gene expression levels in complex biological systems. Among these are knowledge of how...
Read More »Demystifying Single-Cell Spatial Biology with CosMx SMI
CosMx™ Spatial Molecular Imager (SMI) data is flat-out awe-inspiring: even a perfunctory analysis of a single run produces a terabyte of data, gorgeous images (see below), and spatial relationships...
Read More »Comparative analysis of bioinformatics tools to characterize SARS-CoV-2 subgenomic RNAs
During the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), positive-sense genomic RNA and subgenomic RNAs (sgRNAs) are synthesized by a discontinuous process of transcription characterized by a template switch, regulated...
Read More »Do you wonder what 10X data looks like on the newest Illumina sequencer?
Single-cell analysis can help tease apart heterogeneity in complex cell populations, distinguishing cell types and revealing dynamic cell states. The 10x Genomics Chromium Single Cell Multiome ATAC + Gene Expression prepares sequencing...
Read More »Enhance the biological interpretation of RNA-Seq Gene Expression Signatures with Spatial Transcriptomics
With the development of transcriptomic technologies that profile gene expression in situ with spatial context, it is now possible to evaluate the utility of RNA or protein expression signatures for tumor...
Read More »Why are researchers going beyond mutations to study cancer?
Cancer is an incredibly complex system, and researchers in Toronto have found that mutations alone are not enough to fully understand diverse cancers. Each layer of regulation – genome...
Read More »A New AI Tool Predicts Gene Expression in a Single Cell
An artificial intelligence tool, scGPT, can identify cell types, predict the effects of disrupting genes, and pinpoint which genes interact with each other. Scientists investigate disease targets by studying...
Read More »NASA GeneLab releases workflow for processing RNA sequencing data
GeneLab wrapped the RNA sequencing concensus pipeline (RCP) into a Nextflow workflow, which is a workflow manager that enables reproducible and...
Read More »Researchers to explore bone marrow research using expansion sequencing (ExSeq)
Expansion Sequencing (ExSeq) is the process of expanding microscopic particles in order to locate various RNA molecules within cells and tissues...
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