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Sometimes, analyzing our DNA sequences isn’t quite enough. RNA-seq is a next-generation sequencing (NGS)-based technique that looks at the RNA transcripts produced from our DNA, allowing us to...

A new precision medicine platform utilizing both DNA and RNA sequencing helps identify targeted therapy options for patients with relapsed or refractory multiple myeloma. Multiple myeloma (MM) is a malignancy of plasma cells, with a median survival...

The field of epigenetics is branching down many new and exciting avenues. One of these avenues is the area of RNA modification research. Recent advancements in the development of RNA modification detection and sequencing methods...

To date there has been no curated list of NGS methods excepting Illumina’s “For all you seq” posters. Researchers at AstraZeneca have created an open-access Wiki (http://www.enseqlopedia.com/enseqlopedia) that describes over 300 methods and lists relevant publications, including the primary reference.

CMU Software Assembles RNA Transcripts More Accurately 1,584 Views Researchers produce the first draft cell atlas of the small intestine 1,621 Views ExpressionDB – An open source platform for distributing genome-scale datasets 1,768 Views RefEx – a reference gene expression ...

You may have heard about the wonderful things you can find in the raw data your lab produces. Some of it gets published: it becomes part of a groundbreaking study, or inspires the development of a life-saving drug, though most ...

Despite RNA-Seq being the capstone technology for gene expression profiling, qPCR remains the go-to technique for validation. To this day, qPCR validation of microarray data is commonplace, and many see it as necessary, given that microarrays involve hybridization to a glass ...

RNA sequencing (RNA-Seq) and microarray are two of the most commonly used high-throughput technologies for transcriptome profiling; however, they both have their own inherent strengths and limitations. Researchers from Fudan University aimed to analyze the correlation between microarrays and RNA-Seq detection of ...

News Medical Life Sciences by By Catherine Shaffer, M.Sc. – If DNA is the fundamental code of the genome, RNA is the message. Genes are made active through the process of transcribing the code into RNA, and then translating RNA into DNA. This is known as ...

RNA sequencing (RNA-seq) and microarrays are two transcriptomics techniques aimed at the quantification of transcribed genes and their isoforms. Here researchers from the Luxembourg Institute of Health compare the latest Affymetrix HTA 2.0 microarray with Illumina 2000 RNA-seq for the ...