Assistant professor of Ophthalmology and Visual Science and of pathology Brian Hafler and his team have successfully sequenced the RNA of the human..
Read More »A mouse tissue atlas of small noncoding RNA
Small noncoding RNAs (ncRNAs) play a vital role in a broad range of biological processes both in health and disease. A comprehensive quantitative reference of small ncRNA expression would significantly advance our understanding of ncRNA roles in shaping tissue functions. ...
Read More »A single-cell landscape of high-grade serous ovarian cancer
Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor prognosis. To comprehensively characterize the HGSOC ascites ecosystem, a team...
Read More »Direct RNA sequencing and early evolution of SARS-CoV-2
Fundamental aspects of SARS-CoV-2 biology remain to be described, having the potential to provide insight to the response effort for this high-priority pathogen. University of Melbourne researchers...
Read More »The full-length transcriptome of C. elegans using direct RNA sequencing
Current transcriptome annotations have largely relied on short read lengths intrinsic to the most widely used high-throughput cDNA sequencing technologies. For example, in the annotation of the Caenorhabditis elegans transcriptome, more than half of the transcript isoforms lack full-length support and instead ...
Read More »Single cell RNA-Seq reveals the full life cycle of unicellular organisms
Plasmodium parasites, the causative agent of malaria, are single-celled organisms with distinct morphological developmental stages each specialized to inhabit vastly different environments...
Read More »The transcriptional landscape of polyploid wheat
Wheat is one of the major sources of food for much of the world. However, because bread wheat's genome is a large hybrid mix of three separate subgenomes, it has been difficult to produce a...
Read More »RNA-Seq reveals the extent of small RNAs representation in the human genome
While the amount of small non-coding RNA sequencing data is continuously increasing, it is still unclear to which extent small RNAs are...
Read More »NOAA researchers construct the first beluga whale blood transcriptome
Assessing the health of marine mammal sentinel species is crucial to understanding the impacts of environmental perturbations on marine ecosystems and human health. In Arctic regions, beluga whales, Delphinapterus leucas, are upper level predators that may serve as a sentinel ...
Read More »Sequencing and de novo transcriptome assembly of the Chinese giant salamander (Andrias davidianus)
Next-generation technologies for determination of genomics and transcriptomics composition have a wide range of applications. Andrias davidianus, has become an endangered amphibian species of salamander endemic in China. However, there is a lack of the molecular information. In this study, ...
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