Direct RNA sequencing and early evolution of SARS-CoV-2
Fundamental aspects of SARS-CoV-2 biology remain to be described, having the potential to provide insight to the response effort for this high-priority pathogen. University of Melbourne researchers...
The full-length transcriptome of C. elegans using direct RNA sequencing
Current transcriptome annotations have largely relied on short read lengths intrinsic to the most widely used high-throughput cDNA sequencing technologies. For example, in the annotation of the Caenorhabditis elegans transcriptome, more than half of the transcript isoforms lack full-length support and instead ...
Single cell RNA-Seq reveals the full life cycle of unicellular organisms
Plasmodium parasites, the causative agent of malaria, are single-celled organisms with distinct morphological developmental stages each specialized to inhabit vastly different environments...
The transcriptional landscape of polyploid wheat
Wheat is one of the major sources of food for much of the world. However, because bread wheat's genome is a large hybrid mix of three separate subgenomes, it has been difficult to produce a...
RNA-Seq reveals the extent of small RNAs representation in the human genome
While the amount of small non-coding RNA sequencing data is continuously increasing, it is still unclear to which extent small RNAs are...
NOAA researchers construct the first beluga whale blood transcriptome
Assessing the health of marine mammal sentinel species is crucial to understanding the impacts of environmental perturbations on marine ecosystems and human health. In Arctic regions, beluga whales, Delphinapterus leucas, are upper level predators that may serve as a sentinel ...
Sequencing and de novo transcriptome assembly of the Chinese giant salamander (Andrias davidianus)
Next-generation technologies for determination of genomics and transcriptomics composition have a wide range of applications. Andrias davidianus, has become an endangered amphibian species of salamander endemic in China. However, there is a lack of the molecular information. In this study, ...
A more refined equine transcriptome
Transcriptome interpretation relies on a good-quality reference transcriptome for accurate quantification of gene expression as well as functional analysis of genetic variants. The current annotation of the horse genome lacks the specificity and sensitivity necessary to assess gene expression especially ...
A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas
Although the function of the mammalian pancreas hinges on complex interactions of distinct cell types, gene expression profiles have primarily been described with bulk mixtures. Here researchers from the Israel Institute of Technology implemented a droplet-based, single-cell RNA-seq method to ...
Using RNA-seq for genomic scaffold placement, correcting assemblies, and genetic map creation
Brassica rapa is a model species for agronomic, ecological, evolutionary and translational studies. Here researchers from the University of California at Davis describe high-density SNP discovery and genetic map construction for a Brassica rapa recombinant inbred line (RIL) population derived ...
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- Upcoming Workshop – Advanced Topics in Single Cell RNA-Seq Analysis: Multiomics ATAC-Seq & RNA-Seq
- BAP-seq – bioorthogonal masked acylating agents for proximity-dependent RNA labelling
- Single-cell RNA-seq of the rare virosphere reveals the native hosts of giant viruses in the marine environment
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