Technology

The toxicogenomics field aims to understand and predict toxicity by using ‘omics’ data in order to study systems-level responses to compound treatments. In recent years there has been a rapid increase in publicly available toxicological and ‘omics’ data, particularly gene ...

Allele-specific transcriptional regulation, including of imprinted genes, is essential for normal mammalian development. While the regulatory regions controlling imprinted genes are associated with DNA methylation (DNAme) and specific histone...

With the advent of the age of big data in bioinformatics, large volumes of data and high performance computing power enable researchers to perform re-analyses of publicly available datasets...

This RNA-seq workshop will address critical issues related to Transcriptomics data, like: Processing raw Next Generation Sequencing (NGS) data: 1. Next Generation Sequencing data preprocessing: Trimming technical sequences Removing PCR duplicates 2. RNA-seq based quantification of expression levels: Conventional pipelines ...

Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the epithelial subsets of the gastrointestinal tract. Nevertheless, functional studies of these subsets at scale require faithful in vitro models of ...

By leveraging tumorgraft (PDX) RNA-Seq data, researchers at the University of Texas Southwestern Medical Center developed an empirical approach, DisHet, to dissect the tumor microenvironment (eTME). They found that 65% of previously defined immune signature genes are not abundantly expressed ...

RNA is emerging as a key regulator of a plethora of biological processes. While its study has remained elusive for decades, the recent advent of high-throughput sequencing technologies provided the unique opportunity to develop novel techniques for the study of ...

Owing to the advent of high throughput single cell transcriptomics, past few years have seen exponential growth in production of gene expression data. Recently efforts have been made by various research groups to homogenize and store single cell expression from ...

The importance of RNA splicing in numerous cellular processes is well established. However, an underappreciated aspect is the ability of the spliceosome to recognize a set of very small (3-30 nucleotide, 1-10 amino acid) exons named microexons...

New publication: Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach https://biologydirect.biomedcentral.com/articles/10.1186/s13062-018-0214-9#Sec5 Abstract Background One of the main current challenges in computational biology is to make sense of the huge amounts of multidimensional experimental data that are being ...