RNA-Seq Blog Transcriptome Research & Industry News
N6-methyladenosine (m6A) is an abundant RNA modification that plays critical roles in RNA regulation and cellular function. Global m6A...
Read More »scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells
A novel prognostic model based on single-cell RNA sequencing data for hepatocellular carcinoma
The tumour heterogeneous make-up of immune cell infiltrates is a key factor for the therapy response and prognosis of hepatocellular carcinoma (HCC)....
Read More »Dual RNA-Seq analysis of SARS-CoV-2 correlates specific human transcriptional response pathways directly to viral expression
The SARS-CoV-2 pandemic has challenged humankind’s ability to quickly determine the cascade of health effects caused by a novel infection. Even with the unprecedented speed at which vaccines were...
Read More »Quick determination of RNA-Seq strandedness
Quality control checks are the first step in RNA-Sequencing analysis, which enable the identification of common issues that occur in the sequenced reads. Checks for sequence quality, contamination...
Read More »Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose–response study designs
The application of single-cell RNA sequencing (scRNAseq) for the evaluation of chemicals, drugs, and food contaminants presents the opportunity to consider cellular heterogeneity in pharmacological and...
Read More »Massively parallel direct RNA sequencing enables scientists to build ‘valves’ in DNA to shape biological information flows
Scientists at the University of Bristol have developed new biological parts that are able to shape the flow of cellular processes along DNA. The work, now published in the journal Nature Communications, offers a...
Read More »Comprehensive evaluation of noise reduction methods for single-cell RNA sequencing data
Normalization and batch correction are critical steps in processing single-cell RNA sequencing (scRNA-seq) data, which remove technical effects and...
Read More »SwabSeq – Scalable, Sensitive and Fast COVID-19 Testing
The UCLA–developed diagnostic technology has helped keep the university and other large client organizations operational during the pandemic. After much of Los Angeles went dark in the spring of 2020
Read More »BASiCS workflow – a step-by-step analysis of expression variability using single cell RNA sequencing data
Cell-to-cell gene expression variability is an inherent feature of complex biological systems, such as immunity and development. Single-cell RNA sequencing is a powerful tool to quantify this heterogeneity...
Read More »Single cell RNA sequencing reveals that early prostate cancers can harbor aggressive tumor cells
Many cases of early prostate cancer are dominated by cells that are slow-growing, often leading to a clinical decision to monitor for progression before...
Read More »