Using cutting-edge single cell RNA sequencing technology, which the researchers developed specifically for studying these cells in bone, the team found that the new cells switched on a number of...
Read More »DEBKS – a tool to detect differentially expressed circular RNA
Circular RNAs (circRNAs) are involved in various biological processes and disease pathogenesis. However, only a small number of functional circRNAs have been identified among hundreds of thousands of circRNA species, partly because most current...
Read More »Single-cell RNA and protein expression in relation to cell cycle progression
Today researchers within the Human Protein Atlas (HPA) publish a study of single-cell RNA and protein expression in relation to cell cycle progression in...
Read More »Evaluating capture sequence performance for single-cell CRISPR activation experiments
The combination of single-cell RNA sequencing with CRISPR inhibition/activation provides a high-throughput approach to simultaneously study the...
Read More »Single-cell mapper (scMappR) – using scRNA-seq to infer the cell-type specificities of differentially expressed genes
RNA sequencing (RNA-seq) is widely used to identify differentially expressed genes (DEGs) and reveal biological mechanisms underlying complex biological processes. RNA-seq is often performed on...
Read More »Yale neurologists use RNA sequencing to identify consistent neuroinflammatory response in ICH patients
Understanding how the immune system responds to acute brain hemorrhage could open doors to identifying treatments for this devastating disease. However, up until now, there has been limited...
Read More »Molecular Stethoscope publishes human proof-of-concept study for its cell-free mRNA based NGS liquid biopsy technology platform
Molecular Stethoscope Inc, a precision medicine biotechnology company, announces publication of its human proof-of-concept study describing the stratification of NAFLD/NASH patients with clinically...
Read More »Simplified Drop-seq workflow with minimized bead loss using a bead capture and processing microfluidic chip
Single-cell RNA-sequencing (scRNA-seq) has revolutionized biomedical research by enabling the in-depth analysis of cell-to-cell heterogeneity of tissues with unprecedented resolution. One of the...
Read More »SUGAR-seq – simultaneous detection of glycans, epitopes, and the transcriptome in single cells
Multimodal single-cell RNA sequencing enables the precise mapping of transcriptional and phenotypic features of cellular differentiation states but does not allow for simultaneous integration of critical posttranslational modification data. Researchers from the Peter MacCallum Cancer Centre describe SUrface-protein Glycan And ...
Read More »TransPi – a comprehensive TRanscriptome ANalysiS PIpeline for de novo transcriptome assembly
The use of RNA-Seq data and the generation of de novo transcriptome assemblies have been pivotal for studies in ecology and evolution. This is distinctly true for non-model organisms, where no genome information is available; yet, studies of differential gene ...
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