Technology

scPolyA-seq – comprehensive mapping of alternative polyadenylation site usage and its dynamics at single-cell resolution

rna-seq

Alternative polyadenylation (APA) plays an important role in posttranscriptional gene regulation such as transcript stability and translation efficiency. However, our knowledge about APA dynamics at the single-cell level is largely unexplored. Researchers at Zhengzhou University have developed single-cell polyadenylation sequencing ...

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The mystery of the origins of introns solved

rna-seq

UCSC scientists point to introners as the source of the vast majority of introns, a source of molecular complexity unique to eukaryotes One of the most long-standing, fundamental mysteries of biology surrounds the poorly understood origins of introns. Introns are ...

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