Technology

RNA sequencing (RNA-seq) is a powerful method of transcript analysis that allows for the sequence identification and quantification of cellular transcripts. RNA-seq has many applications including differential gene expression (DE) analysis, gene fusion detection...

Circular RNAs (circRNAs) are generated by backsplicing of immature RNA forming covalently closed loops of intron/exon RNA molecules. Pervasiveness, evolutionary conservation, massive and regulated expression, and posttranscriptional regulatory roles of circRNAs in eukaryotes have been...

The B-cell receptor (BCR) performs essential functions for the adaptive immune system including recognition of pathogen-derived antigens. The vast repertoire and adaptive variation of BCR sequences due to V(D)J recombination and somatic...

Identifying regulons of sigma factors is a vital subtask of gene network inference. Integrating multiple sources of data is essential for correct identification of regulons and complete gene regulatory...

Enormous databases of short-read RNA-seq experiments such as the NIH Sequencing Read Archive are now available. These databases could answer many questions about condition-specific...

RNA-seq used to compare the response to infection with 10 different pathogens. Uncovers a group of 252 genes induced by all bacteria. These genes are the core of the immune response. http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006847

To understand stem cell differentiation along multiple lineages, it is necessary to resolve heterogeneous cellular states and the ancestral relationships between them. Researchers from the Max Planck Institute of Immunobiology and Epigenetics developed a robotic miniaturized CEL-Seq2 implementation to carry ...

Bioinformatics is a discipline that requires a combination of skills from the biological, computational, and statistical sciences. Many programs prioritize the technical aspects of bioinformatics over the biological concepts and logic of analyses, thus limiting the emphasis on critical thinking, ...

Batch effects are one of the major source of technical variations that affect the measurements in high-throughput studies such as RNA sequencing...

I would like to share to the community of this RNA-Seq blog the presentation made by our company Acobiom about its MaRS database. To download this presentation, please click here: www.acobiom.com/wp-content/uploads/2016/12/mars_pracedays2017.pdf For more information, please contact Acobiom: busdev@acobiom.com