Methods

New software developed by Peter Mac and collaborators is helping patients diagnosed with acute lymphoblastic leukaemia (ALL) to determine what subtype they have. ALL is the most common...

The rate of raw sequence production through Next-Generation Sequencing (NGS) has been growing exponentially due to improved technology and reduced costs. This has enabled researchers to answer many biological questions through "multi-omics"...

Large RNA including mRNA (mRNA) has emerged as an important new class of therapeutics. Recently, this has been demonstrated by two highly efficacious vaccines based on mRNA sequences encoding for a modified version of the SARS-CoV-2 spike protein. There is ...

Single-cell RNA-sequencing (scRNA-seq) is being used extensively to measure the mRNA expression of individual cells from deconstructed tissues, organs and even entire organisms to generate cell atlas...

The COVID-19 pandemic has created an urgent need for rapid, effective, and low-cost SARS-CoV-2 diagnostic testing. Researchers at the University of Pennsylvania Perelman School of Medicine describe...

Researchers from the University of Auckland have developed ICARUS, a web server to enable users without experience in R to undertake single cell...

There is a strong need to eliminate batch-specific differences when integrating single-cell RNA-sequencing (scRNA-seq) datasets generated under different experimental conditions for downstream...

The subcellular localization of specific RNA molecules promotes localized cellular activity across a variety of species and cell types. The misregulation of this RNA targeting can result in developmental defects, and mutations in proteins that regulate this process are associated ...

Stanford University School of Medicine researchers have developed NEAT-seq (sequencing of nuclear protein epitope abundance, chromatin accessibility and the transcriptome in single cells), enabling...

A new software tool makes it easier to study relationships between a host, its microbiome and pathogens like HIV or SARS-CoV-2. Researchers...