Analysis Pipelines

Researchers from the Institute of Experimental Biology and Technology, Portugal introduce miRPursuit, a pipeline developed for running end-to-end analyses of high-throughput small RNA...

Long non-coding RNAs (lncRNAs) have been implicated in human pathology, however, their role in colorectal carcinogenesis have not been fully elucidated. In the current study, researchers from Baylor...

Next Generation Sequencing (NGS) technologies generate a large amount of high quality transcriptome datasets enabling the investigation of molecular processes on a genomic and...

Long non-coding RNA (lncRNA) is a large class of gene transcripts with regulatory functions discovered in recent years. Many more are expected to be...

With the increasing number of studies focusing on PIWI-interacting RNA (piRNAs), it is now pertinent to develop efficient tools dedicated towards piRNA analysis. Researchers at the National Institute of...

Single-cell RNA sequencing (scRNA-seq) is a frontier research area that studies genomic events down to the individual cell level, providing unprecedented insights into many biological and medical questions, such as cancer heterogeneity and tumor...

Since the small RNA-sequencing (sRNA-seq) technology became available, it allowed the discovery of thousands new microRNAs (miRNAs) in humans and many other species, providing new data on these small RNAs (sRNAs) of high biological and translational relevance. MiRNA discovery has ...

Although many tools have been developed to analyze small RNA sequencing (sRNA-Seq) data, it remains challenging to accurately analyze the small RNA population, mainly due to multiple sequence ID assignment caused by short read length. Additional issues in small RNA ...

Since experimental elucidation of gene function is often laborious, various in silico methods have been developed to predict gene function of uncharacterized genes. Since functionally related genes are often expressed in the same tissues, conditions and developmental stages (co-expressed), functional ...

As a revolutionary technology for life sciences, RNA-seq has many applications and the computation pipeline has also many variations. Researchers from the Functional Genomics Center Zurich describe a protocol to perform RNA-seq data analysis where the aim is to identify differentially ...