Automatic cell type annotation methods are increasingly used in single-cell RNA sequencing (scRNA-seq) analysis due to their fast and precise advantages. However, current methods often fail to...
Read More »Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity
Methods for cell clustering and gene expression from single-cell RNA sequencing (scRNA-seq) data are essential for biological interpretation of cell processes. Researchers at the University of Queensland have...
Read More »scAnnotate – an automated cell type annotation tool for single-cell RNA-sequencing data
Single-cell RNA-sequencing (scRNA-seq) technology enables researchers to investigate a genome at the cellular level with unprecedented resolution...
Read More »SPICEMIX enables integrative single-cell spatial modeling of cell identity
Spatial transcriptomics can reveal spatially resolved gene expression of diverse cells in complex tissues. However, the development of computational...
Read More »scMDR – learning cell annotation under multiple reference datasets by multisource domain adaptation
Accurate and efficient cell type annotation is essential for single-cell sequence analysis. Currently, cell type annotation using well-annotated reference..
Read More »DLNLRR – non-negative low-rank representation based on dictionary learning for single-cell RNA-sequencing data analysis
In the analysis of single-cell RNA-sequencing (scRNA-seq) data, how to effectively and accurately identify cell clusters from a large number of cell mixtures is still a challenge. Low-rank representation...
Read More »sc-linker – identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetic
Genome-wide association studies provide a powerful means of identifying loci and genes contributing to disease, but in many cases, the related cell types...
Read More »RNA-sensing system measures and controls protein expression in cells
A new technology called RADARS allows scientists to detect and target specific cell types, opening up potential applications in diagnostics and therapeutics. Researchers at the Broad Institute of...
Read More »Combining denoising of RNA-seq data and flux balance analysis for cluster analysis of single cells
Sophisticated methods to properly pre-process and analyze the increasing collection of single-cell RNA sequencing (scRNA-seq) data are increasingly...
Read More »CellMap – in silico cell type decomposition is an efficient, inexpensive, and convenient alternative to scRNA-Seq that can leverage bulk RNA-seq
Induced pluripotent stem cell (iPSC) derived cell types are increasingly employed as in vitro model systems for drug discovery. For these studies to be meaningful, it is important to understand the reproducibility of the iPSC-derived cultures and their...
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