GARAGE improves rare cell detection in single-cell RNA sequencing analysis using AI
GARAGE uses artificial intelligence to generate realistic single-cell RNA sequencing data, improving rare cell representation, gene selection and cell clustering in complex biological datasets...
Single-cell RNA sequencing provides a closer look at the Aedes aegypti midgut
Single-cell RNA sequencing, or scRNA-seq, has given researchers a way to examine gene activity one cell at a time. Unlike traditional bulk RNA sequencing, which measures RNA from many cells together and produces an averaged signal, scRNA-seq can reveal ...
Atlas of the brain’s striatum could guide researchers to new drug treatments
A new study reveals insights into populations of neurons affected by Huntington’s disease, schizophrenia, addiction, and other disorders. A region of the brain called the striatum is critical for many cognitive and motor functions, including decision-making, control of movement, ...
scImmuneCo – a compendium of cell-type-specific functional modules for decoding immune responses from single-cell RNA-seq data
The immune system is made up of many different types of cells, each with its own specialized role. During infection, inflammation, or autoimmune disease, these cells do not all respond in the same way. Understanding those differences is essential ...
Spatial map of bladder cancer reveals hidden tumor environments and new paths toward precision therapy
Spatial map of a muscle-invasive bladder cancer tissue specimen at single-cell resolution, showing basal-like cancer cells (pink), luminal cancer cells (green), and intermediate-state cancer cells (light green). Additional cell populations include cancer-associated fibroblasts (yellow), macrophages (salmon), T cells (light ...
Single-cell atlas reveals new insights into Crohn’s disease
Crohn’s disease is a chronic inflammatory bowel disease that affects millions of people worldwide. Although researchers have identified many genetic and environmental factors associated with the disease, patients often experience very different symptoms and responses to treatment. Understanding the ...
RNA sequencing sheds light on how early pancreas lesions become cancerous
Immunofluorescence image of human donor pancreas with a precursor lesion lined by epithelial cells surrounded by fibroblasts. Credit: Pasca Lab In an unexpected finding, a new study flips on its head researchers’ understanding of how precancerous pancreas lesions evolve ...
A spatial atlas of the healthy human liver reveals new insights into gene expression
A first-of-its-kind genetic atlas reveals how human liver cells divide their labor – and why some regions are especially vulnerable to fatty liver disease If scientists could shrink themselves to microscopic size and take a journey through the human ...
Researchers create revolutionary database to map neocortical development across species
Result Could Lead to Treatments for ASD, Schizophrenia, and Dementia Researchers have described major advances in the understanding of the development of the neocortex —layer-by-layer and cell-by-cell—thanks to a pioneering database developed at the University of Maryland School of ...
Cellular ‘atlas’ of prostate cancer opens new avenues for earlier detection
The newly discovered cell type (yellow) shown clustering around a prostate cancer nerve bundle. Prostate cancer affects one in five Australian men, making it the most common cancer in the country. Now, researchers at the Garvan Institute of Medical ...
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Most Shared Posts
- Upcoming Conference – The Festival of Genomics & Biodata
- Gene trajectory inference for single-cell data by optimal transport metrics
- Upcoming Workshop – Advanced Topics in Single Cell RNA-Seq Analysis: Multiomics ATAC-Seq & RNA-Seq
- BAP-seq – bioorthogonal masked acylating agents for proximity-dependent RNA labelling
- Single-cell RNA-seq of the rare virosphere reveals the native hosts of giant viruses in the marine environment
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