Imagine a virtual human body, rich in complexity and detail, that enables scientists to simulate experiments that can’t be conducted in vivo or...
Read More »A spatially resolved atlas of the human lung characterizes a gland-associated immune niche
Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well...
Read More »Mount Sinai researchers present a comprehensive, single-nucleus RNA sequencing atlas of late prenatal human development
Late prenatal development of the human neocortex encompasses a critical period of cortical expansion and glial development (cells that are essential to the central nervous system), which is poorly understood...
Read More »Impact of the Human Cell Atlas on medicine
Single-cell atlases promise to provide a ‘missing link’ between genes, diseases and therapies. By identifying the specific cell types, states, programs and contexts where disease-implicated genes act...
Read More »Systematic characterization of cancer transcriptome at transcript resolution
Transcribed RNAs undergo various regulation and modification to become functional transcripts. Notably, cancer transcriptome has not been fully characterized at transcript resolution. Researchers at the Shanghai Jiao Tong University School of Medicine carried out a reference-based transcript assembly across >1000 ...
Read More »High temporal resolution Nanopore sequencing dataset of SARS-CoV-2 and host cell RNAs
Recent studies have disclosed the genome, transcriptome, and epigenetic compositions of severe acute respiratory syndrome coronavirus...
Read More »RiceNCexp – a rice non-coding RNA co-expression atlas based on massive RNA-seq and small-RNA seq data
Non-coding RNAs (ncRNAs) play important roles in regulating expression of protein-coding genes. Although gene expression databases have emerged in a timely manner, a comprehensive expression...
Read More »Pan-cancer single-cell RNA-sequencing analysis reveals cancer cell states recur across tumor types
Transcriptional heterogeneity among malignant cells of a tumor has been studied in individual cancer types and shown to be organized into cancer cell states; however, it remains unclear to what extent these states span tumor types, constituting general features of ...
Read More »PlaqView 2.0 – A comprehensive web portal for cardiovascular single-cell genomics
Single-cell RNA-seq (scRNA-seq) is a powerful genomics technology to interrogate the cellular composition and behaviors of complex systems. While the number of scRNA-seq datasets and available computational analysis tools have grown...
Read More »Cell by cell, scientists are building a high-resolution map of brain changes in Alzheimer’s disease
Alzheimer’s disease wreaks unmistakable havoc in the brain. If you compare the brain of someone who has died from neurodegenerative disease to that of...
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