Atlas of the brain’s striatum could guide researchers to new drug treatments
A new study reveals insights into populations of neurons affected by Huntington’s disease, schizophrenia, addiction, and other disorders. A region of the brain called the striatum is critical for many cognitive and motor functions, including decision-making, control of movement, ...
Genetic mapping identifies new hope for bone diseases
More than half of the genes the researchers identified have never been shown to play a role in maintaining bone health. An image of an epiphyseal plate, the area at the end of bones where new bone is formed. ...
Chimeric RNAs expand the potential of RNA sequencing for disease detection
RNA sequencing has become an essential tool for understanding how genes function in health and disease. In addition to measuring normal gene expression, it can also detect unusual RNA molecules called chimeric RNAs, which are formed when parts of ...
A Hormone Cell Atlas maps the human endocrine system at cellular resolution
Hormones are chemical messengers that help coordinate many of the body's most important functions, including growth, metabolism, reproduction, and immune responses. Although scientists have studied individual hormones for decades, it has been difficult to create a complete picture of ...
NIH’s All of Us Research Program is now the largest integrated genomics and health database in the world
The latest release adds RNA sequencing (RNA-Seq) data from nearly 9,000 participants. The National Institutes of Health (NIH) has issued the most expansive data release in the history of its All of Us Research Program, making available data from ...
New RNA interaction atlas expands understanding of gene regulation
RNA molecules do much more than simply carry instructions for making proteins. Inside cells, RNA molecules constantly interact with other RNAs and with proteins called RNA-binding proteins, or RBPs. These interactions help control how genes are turned on and ...
Researchers create revolutionary database to map neocortical development across species
Result Could Lead to Treatments for ASD, Schizophrenia, and Dementia Researchers have described major advances in the understanding of the development of the neocortex —layer-by-layer and cell-by-cell—thanks to a pioneering database developed at the University of Maryland School of ...
RMzyme – regulations of RNA-modifying enzymes in humans
Inside every cell, RNA molecules help carry genetic instructions and guide the production of proteins. These RNA molecules are not static. They can be chemically modified after they are made, and these modifications can influence how stable the RNA ...
The GENCODE CLS project – massively expanding the lncRNA catalog through capture long-read RNA sequencing
Understanding how genomes work depends on knowing where genes are and what they produce. While protein-coding genes are relatively well annotated, long non-coding RNAs, or lncRNAs, have remained one of the least understood parts of the genome. These RNAs ...
PERlncDB – new platform developed to explore epigenetic regulation of plant long non-coding RNAs
Long non-coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins. Once considered mere transcriptional noise, lncRNAs are now known to play vital roles in plant growth, development, and responses to environmental stress. However, ...
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