Decima predicts gene expression at single-cell resolution
Genes are controlled by regulatory DNA sequences that determine when and where genes are turned on. Understanding how these DNA sequences influence gene expression is one of the major goals of modern genomics. Over the past several years, researchers ...
Single-cell total RNA sequencing expands our view of gene regulation
Understanding how genes are turned on and off in individual cells is essential for studying development and disease. Most single cell RNA sequencing methods focus on polyadenylated RNA, which mainly captures protein coding transcripts, but misses many important noncoding ...
A new RNA sequencing method reveals hidden diversity in drug-resistant lung cancer cells
Understanding how cancer cells respond to treatment is one of the biggest challenges in biology. Even within the same tumor, cells can behave very differently, which makes it harder to fully eliminate the disease. Researchers at The Hebrew University ...
New sequencing method exposes hidden gaps in immune signaling
A new single-cell technology is giving scientists their clearest view yet of immune cell behavior—capturing not just genetic intent but real-time activity. By measuring RNA and proteins simultaneously, it reveals cytokine activity with greater accuracy, strengthening the foundation for ...
In vivo RNA sequencing reveals real-time immune response to infection
Understanding how the immune system responds to infection requires tracking how cells change over time. Researchers at the Chinese Academy of Sciences have developed a new method to observe how immune cells activate and respond during infection at the ...
RNA sequencing moves toward absolute measurement of gene expression
RNA sequencing has become a powerful tool for measuring gene activity, but it has an important limitation. The number of sequencing reads does not always directly reflect the true amount of RNA in a sample. Researchers at Fudan University ...
Improving small RNA analysis with a new miRNA alignment tool
Small non-coding RNAs, often abbreviated as sncRNAs, are short RNA molecules that play important roles in regulating gene expression. Among them, microRNAs, or miRNAs, are especially well known for controlling how messenger RNA is translated into proteins. Because of ...
RNA-seq analysis in seconds using GPUs
Modern biology generates enormous amounts of sequencing data, especially from RNA sequencing, which measures how genes are expressed inside cells. Analyzing these datasets can take significant computing time, even with efficient tools. A new report led by researchers at ...
A chatbot simplifies RNA sequencing data analysis
RNA sequencing has become a standard method for measuring gene expression across thousands of genes at once. While the technology itself is powerful, analyzing the resulting data can be complex. Researchers often need bioinformatics expertise to select appropriate statistical ...
Mapping protein production in brain cells yields new insights for brain disease
UC San Diego and Scripps Research scientists used a novel method to show that some memory neurons produce proteins at higher rates than others. A new method lets researchers visualize messenger RNA translation across different brain cell types. In ...
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