Nanopore direct RNA sequencing reveals the challenges of detecting RNA modifications
RNA molecules are not simply copied from DNA and sent directly to make proteins. They can also undergo chemical modifications that influence how they are processed, stabilized and used inside cells. Collectively, these changes are part of the epitranscriptome. ...
Nanopore RNA sequencing maps mitochondrial tRNA modifications in yeast
Transfer RNAs, commonly called tRNAs, are essential molecules that help cells build proteins. Before they can perform this job, many tRNAs undergo small chemical changes called base modifications. These modifications help the molecules fold correctly, remain stable, and accurately ...
QutRNA2 – robust tRNA modification discovery from Nanopore direct tRNA sequencing
Transfer RNAs, or tRNAs, play a critical role in protein production by delivering amino acids to the ribosome during protein synthesis. These small RNA molecules also contain numerous chemical modifications that help maintain their structure and function. Understanding these ...
Systematic benchmarking of dorado basecalling models for RNA modification detection
..Nanopore RNA sequencing models can detect RNA modifications, but benchmark results reveal significant false positives and highlight the importance of controls for accurate epitranscriptomic analysis.
m6A-ARTR-DBiT – mapping RNA modifications across tissues with spatial m6A profiling
RNA molecules carry more information than just the genetic instructions used to make proteins. They also contain chemical modifications that can influence how genes are regulated. One of the most common and important of these modifications is N6-methyladenosine, commonly ...
Nanopore sequencing advances pseudouridine detection in ribosomal RNA
RNA molecules contain more than just the four standard nucleotide bases. After RNA is produced, cells often modify individual nucleotides through a variety of chemical changes that can influence RNA stability, structure, and function. One of the most common ...
Benchmarking nanopore RNA sequencing for m6A detection
RNA molecules can carry chemical marks that influence how they function inside cells. One of the most important of these marks is N6-methyladenosine, or m6A. This modification can affect RNA stability, translation, and gene regulation, making it important for ...
Systematic assessment of diverse RNA modifications using nanopore direct RNA sequencing
RNA molecules are not just simple copies of genetic instructions. They can carry chemical modifications that affect how stable they are, how they interact with cells, and how well they work as medicines. These modifications are especially important in ...
Fusion-m6A – a lightweight hybrid deep learning framework for RNA m6A site prediction
Chemical modifications on RNA play an important role in how genes are regulated inside cells. One of the most common of these modifications is called m6A, which affects how RNA molecules are processed, translated into proteins, and ultimately how ...
FIRST-seq – a nanopore-based cDNA sequencing platform for RNA modification and structure profiling
RNA sequencing using nanopore technology enables detection of RNA modifications and structure at single-nucleotide resolution through reverse transcription error signatures...
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