Statistical Analysis

Information-theory-based benchmarking and feature selection algorithm improve cell type annotation and reproducibility of single cell RNA-seq data analysis pipelines

rna-seq

Single cell RNA sequencing (scRNA-seq), which promises to enable the quantitative study of biological processes at the single cell level, are now a routine part of experimental practice. One key computational challenge in analyzing scRNA-seq data is cell type annotation. ...

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Modeling RNA dynamics without metabolic labeling

Transcript’s abundance is typically considered a proxy of the corresponding genes transcriptional activity. Yet, a poorly transcribed gene could see many of its RNA molecules accumulate just because they are highly stable. Conversely, if a gene is very actively transcribed ...

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