Unlocking the past – new method helps gain insights into old tissue
A book sits atop a table. Although it’s closed, its title, “Encyclopedia of Human Tissue,” promises untold secrets. Perhaps with this book, you can learn about different cell types and what they look like under normal conditions or conditions ...
New approach reveals how complete riboswitches control gene expression
Riboswitches are specialized RNA molecules that help bacteria regulate gene activity. These molecules can change their shape in response to specific chemicals, allowing them to turn genes on or off when needed. Scientists have learned a great deal about ...
Gel-free library preparation for next-generation RNA sequencing and small RNA quantification
RNA sequencing is widely used to measure RNA molecules and understand how cells regulate gene activity. However, small RNA sequencing can be technically challenging. During library preparation, unwanted primer dimers can form, and reverse transcriptase enzymes can stop early ...
Improving nucleic acid amplification with machine learning
Amplifying DNA or RNA is a key step in many areas of biology, from disease diagnostics to emerging technologies like DNA-based data storage. However, controlling how efficiently genetic material is copied during amplification is not always easy. Small changes ...
Assessing mRNA and sgRNA quality for cell and gene therapy applications using nanopore direct RNA sequencing
RNA based therapeutics are rapidly expanding across modern medicine. Messenger RNA vaccines, gene editing systems, and RNA based immunotherapies all rely on carefully designed RNA molecules to work correctly. Because these molecules directly influence biological processes inside cells, scientists ...
Ribo-seq Guide: Workflow, QC Metrics, Translational Efficiency, and Method Comparison
Translatomics sequencing complements RNA sequencing by revealing which mRNAs are actively translated, uncovering translational efficiency, ribosome dynamics, and regulatory mechanisms invisible at the transcript level...
A New Method for Nanopore Direct RNA-Seq Pushes the Limits of Long Transcript Identification and Isoform Resolution
Direct RNA sequencing (DRS) on nanopore platforms promises something short-read methods cannot: native RNA molecules read end-to-end, with isoforms, long transcripts, and RNA modifications preserved. In practice, however, many labs find that conventional DRS workflows underdeliver on that promise...
TIRE-seq simplifies transcriptomics via integrated RNA capture and library preparation
RNA sequencing (RNA-seq) has become a go-to method for exploring how genes are expressed across different biological conditions. It plays a vital role in cancer research, immunology, neuroscience, and developmental biology. However, traditional RNA-seq workflows typically require a time-consuming ...
A simplified preparation method for single-nucleus RNA-sequencing using long-term frozen brain tumor tissues
Researchers at the German Cancer Research Center (DKFZ) have developed a new, streamlined method to isolate nuclei from long-term frozen pediatric glioma tissues—an innovation that could be a game-changer for studying rare brain tumors. Studying tumors at the single-cell level ...
Innovative bead design will enhance single-cell transcriptomics accuracy
Researchers at NDORMS have made an important advancement in the field of single-cell transcriptomics by developing a novel bead design that reduces errors in DNA synthesis and improves the reliability of gene expression measurements. Single-cell transcriptomics has revolutionised the ...
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Most Shared Posts
- Upcoming Conference – The Festival of Genomics & Biodata
- Gene trajectory inference for single-cell data by optimal transport metrics
- Upcoming Workshop – Advanced Topics in Single Cell RNA-Seq Analysis: Multiomics ATAC-Seq & RNA-Seq
- BAP-seq – bioorthogonal masked acylating agents for proximity-dependent RNA labelling
- Single-cell RNA-seq of the rare virosphere reveals the native hosts of giant viruses in the marine environment
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