RNA-Seq Blog Transcriptome Research & Industry News
RNA Polymerase II (Pol II) is a multi-subunit complex that undergoes covalent modifications as transcription proceeds through genes and...
Read More »PRO-IP-seq – tracks molecular modifications of engaged Pol II complexes at nucleotide resolution
scDiffCom – a tool for differential analysis of cell–cell interactions from single-cell transcriptomics data
Dysregulation of intercellular communication is a hallmark of aging. To better quantify and explore changes in intercellular communication, University of Liverpool researchers have developed scDiffCom...
Read More »DiSignAtlas – an atlas of human and mouse disease signatures based on bulk and single-cell transcriptomics
Molecular signatures are usually sets of biomolecules that can serve as diagnostic, prognostic, predictive, or therapeutic markers for a specific disease. Omics data derived from various high-throughput molecular...
Read More »cscQTL – an integrative framework for circular RNA quantitative trait locus discovery
Molecular quantitative trait locus (QTL) mapping has proven to be a powerful approach for prioritizing genetic regulatory variants and causal genes...
Read More »scMultiGAN – cell-specific imputation for single-cell transcriptomes with multiple deep generative adversarial networks
The emergence of single-cell RNA sequencing (scRNA-seq) technology has revolutionized the identification of cell types and the study of cellular states at a single-cell level. Despite its significant...
Read More »Batch-effect correction in single-cell RNA sequencing data using JIVE
In single-cell RNA sequencing (scRNA-seq) data analysis, addressing batch effects – technical artifacts stemming from factors such as varying...
Read More »New method tracks how brain cells age
Hospital nurseries routinely place soft bands around the tiny wrists of newborns that hold important identifying information such as name, sex, mother, and birth date. Researchers at Rockefeller...
Read More »Single-cell RNA sequencing details immune system’s role in metabolic disease
Researchers at Vanderbilt University Medical Center have published the largest single-site adipose tissue atlas known to date. A tissue atlas is a...
Read More »MkcDBGAS – a reference-free approach to identify comprehensive alternative splicing events in a transcriptome
Alternative splicing (AS) is an essential post-transcriptional mechanism that regulates many biological processes. However, identifying comprehensive types of AS events without guidance from a...
Read More »Quantum annealing-based clustering of single cell RNA-seq data
Cluster analysis is a crucial stage in the analysis and interpretation of single-cell gene expression (scRNA-seq) data. It is an inherently ill-posed problem...
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