Using a new single-cell technique, WEHI researchers have uncovered a way to understand the programming behind how stem cells make particular cell types. The research uncovered 30 new genes that program stem cells to make the dendritic cells that...
Read More »scGNN – a novel graph neural network framework for single-cell RNA-Seq analyses
Single-cell RNA-sequencing (scRNA-Seq) is widely used to reveal the heterogeneity and dynamics of tissues, organisms, and complex diseases, but its analyses still suffer from multiple grand challenges, including the sequencing sparsity and complex...
Read More »Model-based deep embedding for constrained clustering analysis of single cell RNA-seq data
Clustering is a critical step in single cell-based studies. Most existing methods support unsupervised clustering without the a priori exploitation of any domain knowledge. When confronted by the high dimensionality and pervasive dropout events...
Read More »Novel guidelines help select optimal deconvolution method
Biomedical scientists are increasingly using deconvolution methods, those used to computationally analyze the composition of complex mixtures of cells. One of their challenges is to...
Read More »SMIXnorm – fast and accurate RNA-Seq data normalization for FFPE Samples
RNA-sequencing (RNA-seq) provides a comprehensive quantification of transcriptomic activities in biological samples. Formalin-Fixed Paraffin-Embedded (FFPE) samples are collected as part of routine clinical procedure, and are the most...
Read More »TEA-seq – simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility
Single-cell measurements of cellular characteristics have been instrumental in understanding the heterogeneous pathways that drive differentiation, cellular responses to signals, and human disease...
Read More »NanoSINC-seq dissects the isoform diversity in subcellular compartments of single cells
Alternative mRNA isoforms play a key role in generating diverse protein isoforms. To dissect isoform usage in the subcellular compartments of...
Read More »A versatile cell fixation-dissociation method for single-cell transcriptomics
Single-cell sequencing technologies are revolutionizing biology, but they are limited by the need to dissociate live samples. Researchers from Oxford Brookes University have developed ACME (ACetic-MEthanol), a dissociation approach for single...
Read More »RNAStructViz – graphical base pairing analysis
Researchers from Georgia Tech have developed a new graphical tool for RNA secondary structure analysis. The central feature is the ability to visually compare/contrast up to three base pairing...
Read More »Spatial mapping of COVID-19 and H1N1 influenza show differential transcriptional signatures
A new study from researchers at the University of Alabama at Birmingham is shining a light on the similarities and differences between COVID-19 and...
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