Unlocking the past – new method helps gain insights into old tissue
A book sits atop a table. Although it’s closed, its title, “Encyclopedia of Human Tissue,” promises untold secrets. Perhaps with this book, you can learn about different cell types and what they look like under normal conditions or conditions ...
Multisite assessment of methods for cell preservation upstream of single-cell RNA sequencing
Single-cell RNA sequencing has become an important tool for understanding the diversity of cells within complex tissues. By examining gene expression in individual cells, researchers can identify cell types and molecular characteristics that are often hidden when analyzing large ...
High-quality acinar cell isolation enables single-cell analysis of healthy and injured pancreas
Studying the pancreas at the single-cell level is essential for understanding diseases like pancreatitis and pancreatic cancer. However, isolating healthy pancreatic cells has been difficult because enzymes in the tissue can quickly damage cells and degrade RNA, making it ...
The world’s oldest RNA extracted from woolly mammoth
Researchers from Stockholm University have for the first time ever managed to successfully isolate and sequence RNA molecules from Ice Age woolly mammoths. These RNA sequences are the oldest ever recovered and come from mammoth tissue preserved in the Siberian ...
Nanostraw electroporation for temporal RNA sampling from living 2D and 3D cell culture systems
Scientists have long faced a major challenge when studying how genes behave inside living cells: to measure gene activity, they usually have to destroy the cells. Traditional methods of RNA extraction rely on cell lysis, a process that breaks ...
Nuclei isolation from adult mouse kidney for single-nucleus RNA-sequencing
Understanding how the kidney works at the level of individual cells is essential for studying health and disease. However, traditional methods for single-cell RNA sequencing (scRNA-seq) in kidney research come with major drawbacks. They typically require fresh tissue and ...
RNA extraction and RNA-sequencing method for transcriptomic analysis of Mycobacterium tuberculosis
Understanding how Mycobacterium tuberculosis, the bacterium responsible for tuberculosis (TB), responds to drugs at the molecular level is key to developing better treatments. A new research protocol developed by researchers from the National Microbiology Laboratory at the Public Health ...
A novel preservation method enables field-based single-cell RNA sequencing of malaria infections
Researchers are making a major leap in malaria research thanks to new advances in single-cell RNA sequencing. Led by researchers at the Institute of Tropical Medicine in Belgium, scientists have validated a way to study individual malaria parasites from ...
A simplified preparation method for single-nucleus RNA-sequencing using long-term frozen brain tumor tissues
Researchers at the German Cancer Research Center (DKFZ) have developed a new, streamlined method to isolate nuclei from long-term frozen pediatric glioma tissues—an innovation that could be a game-changer for studying rare brain tumors. Studying tumors at the single-cell level ...
RNA sequencing from long-stored biobank blood samples
Biobanks store vast amounts of frozen blood samples, offering an invaluable resource for medical research. However, one major hurdle has been extracting high-quality RNA from these samples—especially when stored for long periods without RNA-preserving chemicals. Researchers at Umeå University have ...
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