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Microdroplet single-cell ATAC-seq is widely used to measure chromatin accessibility, however, highly scalable and simple sample multiplexing procedures are not available. UT MD Anderson Cancer Center...

N6-methyladenosine (m6A) is the most prevalent modification of messenger RNA in mammals. To interrogate its functions and dynamics, there is a critical need to quantify m6A at three levels: site, gene and sample. Current approaches address these needs in a ...

NGS libraries from sRNA are commonly prepared by sequential ligation of adaptors to input RNA 3′ and 5′ ends, often with a gel purification step after each ligation step, followed by cDNA synthesis and PCR...

RNA molecules can fold into complex structures and interact with trans-acting factors to control their biology. Recent methods have been focused on developing novel tools to measure RNA structure...

Dedifferentiation of chondrocyte greatly restricts its function and application, however, it is poorly understood except a small number of canonical markers. The non-cell-adhesive property endows...

After a gene is transcribed into RNA, modifications can occur to the subunits or “bases” that make up the RNA molecule, which can affect its structure...

Researchers have created new algorithms to help meet the need for computational tools that can analyze and extract information from the increasingly large datasets that are being...

At Eclipse BioInnovations (Eclipse Bio), we create tools that simplify, accelerate and advance RNA research. End-Seq technology is a recent development at Eclipse Bio, which we are excited to officially launch this month. Eclipse’s End-Seq products enable researchers to map ...

The integration of viruses into the human genome is known to be associated with tumorigenesis in many cancers, but the accurate detection of integration breakpoints from short read sequencing data is made difficult by human-viral homologies, viral genome heterogeneity, coverage ...

Single-cell sequencing has emerged as an indispensable technology to dissect cellular heterogeneity but never been applied to the simultaneous analysis of glycan and RNA...