Workflows

When biologically interpretation of the data obtained from the single-cell RNA sequencing (scRNA-seq) analysis is attempted, additional information on the location of the single cells, behavior of the...

In recent years, high-throughput single-cell transcriptomics and chromatin accessibility methods have generated numerous resources and provided new insights into the cell heterogeneity of tissues...

FFPE (formalin-fixed, paraffin-embedded) tissue archives are the largest repository of clinically annotated human specimens. Despite numerous advances in technology, current methods for sequencing of FFPE-fixed single-cells are slow, labour...

University of Virginia School of Medicine researchers and their collaborators have created a powerful new tool they say will benefit essentially every area of biomedical research, from understanding how healthy cells function to the battle against cancer and neurodegenerative diseases such as Alzheimer’s. ...

The impact of environmental conditions on the dynamic structures of RNAs in living cells has been revealed by innovative technology developed by...

Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue...

Bladder cancer (BLCA) is one of the most common cancer types worldwide. The disease is responsible for about 200,000 deaths annually, thus improved...

Single-cell sequencing is widely used in biological and medical studies. However, its application with multiple samples is hindered by inefficient sample processing, high experimental costs, ambiguous...

Quantification of gene expression such as RNA-Seq is a popular approach to study various biological phenomena. Despite the development of RNA-Seq library preparation methods and sequencing...

Broad Institute researchers have developed BacDrop, a highly scalable technology for bacterial single-cell RNA sequencing that has overcome many challenges hindering the development of scRNA-seq...