Novel biosensor uses DNA ‘barcodes’ to uncover disease signals in cells
Inspired by bacterial biology, the Gladstone-developed “Detectron” opens up new possibilities for disease research and potentially treatments. Inside every cell, RNA acts as a vital messenger. Its levels rise when genes are active, while specific fragments can serve as ...
Urine test may improve bladder cancer diagnosis and guide treatment decisions
Researchers developed a urine test that detects bladder cancer, predicts which patients will benefit from immunotherapy versus chemotherapy, and can confirm whether treatment worked. simple urine test devised by researchers at Stanford Medicine and the VA Palo Alto Health ...
Single-cell TimeLapse-seq reveals MTA is an essential retrotransposon
Very early in development, an embryo must begin using its own genome instead of relying only on RNA and proteins inherited from the egg. This transition is known as zygotic genome activation, or ZGA, and it is a critical ...
Detection and sequencing of Ap2N-capped RNAs in human cells
RNA molecules are essential for carrying and using genetic information, but their function depends on more than just the sequence of their nucleotides. Chemical structures attached to RNA can influence how RNA is processed, protected, recognized, and broken down ...
Single-cell RNA sequencing provides a closer look at the Aedes aegypti midgut
Single-cell RNA sequencing, or scRNA-seq, has given researchers a way to examine gene activity one cell at a time. Unlike traditional bulk RNA sequencing, which measures RNA from many cells together and produces an averaged signal, scRNA-seq can reveal ...
POND-seq enables non-destructive RNA sequencing in living cells
RNA sequencing is widely used to measure gene activity, but most methods require cells to be broken open or fixed before their RNA can be collected. This means researchers usually get only a single snapshot of gene expression from ...
New method allows scientists to follow gene activity over time in the same cells
Live-cell RNA sequencing uses engineered virus-like particles to repeatedly sample transcriptomes without destroying cells, enabling researchers to track gene expression changes over time...
Single-cell and single-embryo RNA sequencing
Single-cell and single-embryo RNA sequencing enables detailed analysis of gene expression and cell identity during the earliest stages of embryonic development...
scLS – a computationally efficient differentially expressed gene detection algorithm
The proposed algorithm enables pseudotime-based dynamics without the need for explicit regression models or branch assignment Single-cell RNA sequencing (scRNA-seq) is a method to measure gene expression of individual cells, allowing observation of various cellular processes, including cell differentiation, ...
Spatial mapping of RNA turnover kinetics in the mouse brain
Gene expression is often described by measuring how much RNA is present in a cell at a given moment. But RNA levels are constantly changing as new molecules are produced and older ones are broken down. Measuring both processes ...
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- Upcoming Workshop – Advanced Topics in Single Cell RNA-Seq Analysis: Multiomics ATAC-Seq & RNA-Seq
- BAP-seq – bioorthogonal masked acylating agents for proximity-dependent RNA labelling
- Single-cell RNA-seq of the rare virosphere reveals the native hosts of giant viruses in the marine environment
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