How should biological replicates be handled in long-read RNA sequencing?
Long-read RNA sequencing allows researchers to read much larger portions of RNA molecules than traditional short-read methods. This makes it especially useful for identifying transcript isoforms, different versions of RNA produced from the same gene. As long-read RNA sequencing ...
RNA-Seq reveals a new way the developing heart controls its growth
Findings may ultimately have implications for heart repair after a heart attack Northwestern Medicine scientists have uncovered an unexpected part of the answer: lymphatic vessels, long known for transporting fluid and immune cells, also send signals to different cardiac ...
Nanopore direct RNA sequencing reveals the challenges of detecting RNA modifications
RNA molecules are not simply copied from DNA and sent directly to make proteins. They can also undergo chemical modifications that influence how they are processed, stabilized and used inside cells. Collectively, these changes are part of the epitranscriptome. ...
scFlowReport brings multiple single-cell RNA sequencing analyses into one workflow
Single-cell RNA sequencing allows researchers to measure gene activity in individual cells, making it possible to study how different cell types respond to disease, treatment or genetic changes. But generating the sequencing data is only the beginning. Researchers often ...
Long-read RNA sequencing reveals how neurons choose alternative RNA endings
A single gene can produce multiple RNA molecules with different structures. One important process behind this diversity is alternative polyadenylation, or APA, in which cells choose different locations near the end of an RNA transcript where the RNA is ...
DeOPUS improves cell-type estimates from bulk RNA sequencing
Single-cell RNA sequencing allows researchers to examine gene activity in individual cells, making it possible to study the many different cell types within a tissue. However, single-cell experiments can be expensive and technically demanding, especially when large numbers of ...
ResolVI improves accuracy in spatial transcriptomics analysis
Spatial transcriptomics allows researchers to measure gene activity while preserving information about where that activity occurs within a tissue. Unlike conventional RNA sequencing, which often analyzes RNA after cells or tissues have been mixed together, spatial transcriptomics can show ...
RNA sequencing reveals transcriptional allele differences in prostate cancer stem cells
Cancer develops as cells accumulate genetic and molecular changes that alter how they grow, divide and interact with surrounding tissues. In prostate cancer, researchers have identified many changes in DNA that contribute to tumor development and progression. However, less ...
Unmasking “zombie cells” in aging tissue with an AI-powered barcode
Tracking down senescent cells, which accumulate as we age, could help diagnose age-related disorders and guide researchers working on new treatments. As we age, some of the cells in our body enter a state of senescence, in which they ...
Single-cell TimeLapse-seq reveals MTA is an essential retrotransposon
Very early in development, an embryo must begin using its own genome instead of relying only on RNA and proteins inherited from the egg. This transition is known as zygotic genome activation, or ZGA, and it is a critical ...
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