Anindya Dutta, MBBS, Ph.D., and colleagues have described a novel form of gene regulation that is altered in bladder cancer, leading to the boosting...
Read More »Halo-seq – An RNA proximity labeling method for the isolation and analysis of subcellular RNA populations
The subcellular localization of specific RNA molecules promotes localized cellular activity across a variety of species and cell types. The misregulation of this RNA targeting can result in developmental defects, and mutations in proteins that regulate this process are associated ...
Read More »Advances in single-cell multiomic profiling
Single-cell transcriptomic approaches have revolutionised the study of complex biological systems, with the routine measurement of gene expression in thousands of cells enabling...
Read More »Single-nucleus RNA sequencing reveals why a specific type of neuron dies in Parkinson’s disease
Parkinson’s disease is marked by the death of dopamine-producing neurons in the brain — specifically in the substantia nigra, a structure...
Read More »Single-cell RNA sequencing reveals the individual immune cells inside the plaque that causes life-threatening heart attacks
Through single-cell RNA sequencing, a research group has successfully illuminated the characteristics of Myeloid immune cells in coronary plaque, which causes acute coronary syndrome (this term includes...
Read More »NEAT-seq – simultaneous profiling of intra-nuclear proteins, chromatin accessibility and gene expression in single cells
Stanford University School of Medicine researchers have developed NEAT-seq (sequencing of nuclear protein epitope abundance, chromatin accessibility and the transcriptome in single cells), enabling...
Read More »New tool integrates microbiome and host genetic sequencing analysis
A new software tool makes it easier to study relationships between a host, its microbiome and pathogens like HIV or SARS-CoV-2. Researchers...
Read More »Stereo-seq enables first panoramic spatial atlases of life
In a series of studies published in Cell Press journals, STOC members used the spatially resolved transcriptomics technology Stereo-seq, developed by BGI-Research, to produce spatiotemporal cellular...
Read More »New open-source software automates RNA analysis to speed up research and drug development
“Pytheas” app created by a team at Scripps Research allows scientists to identify and quantify modified RNA molecules more easily than ever. Scientists at Scripps Research have unveiled a new software tool for studying RNA (ribonucleic acid) molecules, which have ...
Read More »A comparison of strategies for generating artificial replicates in RNA-seq experiments
Due to the overall high costs, technical replicates are usually omitted in RNA-seq experiments, but several methods exist to generate them artificially...
Read More »