Technology

Tissue culture models of the fetal brain reveal psychosis-associated changes in the cell behavior of the early brain. The brain changes that occur at the onset of psychiatric conditions such as schizophrenia and bipolar disorder could originate from a disturbance ...

Dissecting the cellular heterogeneity embedded in single-cell transcriptomic data is challenging. Although many methods and approaches exist, identifying cell states and their underlying topology is still a major challenge. Here, researchers from the...

Recent technological advances in RNA sequencing and analysis have allowed an increasingly thorough investigation of a previously unexplored class of transcripts, circular (circ)RNAs. Accumulating...

Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. ...

Adding RNA sequencing to exome and genome sequencing can improve diagnostic yield and increase confidence in diagnosis of rare genetic...

A number of alignment methods have been developed to enable the integration and comparison of scRNA-Seq data from studies using different...

Current methods for determining RNA structure with short-read sequencing cannot capture most differences between distinct transcript isoforms. Researchers at A*STAR, Singapore present RNA structure analysis using nanopore sequencing...

The analysis highlights the diversity of immune response in pancreatic cancer, and points toward the need for treatments tailored to individual patients. Stubbornly, frustratingly, pancreatic cancer has...

Cell differentiation and function are regulated across multiple layers of gene regulation, including modulation of gene expression by changes in chromatin accessibility. However, differentiation is an asynchronous process precluding a temporal...

Recent advances allowing the genomic analysis of individual cells from a bulk population have provided intriguing new insights into areas such as developmental processes and tumor heterogeneity. Most...