Publications

Single-cell RNA sequencing has led to unprecedented levels of data complexity. Although several computational platforms are available, performing data analyses for multiple datasets remains a significant challenge. University of Oxford researchers provide a comprehensive analytical protocol to interrogate multiple datasets ...

Genomic and transcriptomic heterogeneity both play important roles in normal cellular function as well as in disease development. To be able to characterize these different forms of cellular heterogeneity in diverse sample types, researchers from the Hong Kong University of ...

Therapeutics based on messenger RNA, or mRNA, can potentially treat a wide range of maladies, including cancer, genetic diseases, and as the world..

Most methods for single-cell transcriptome sequencing amplify the termini of polyadenylated transcripts, capturing only a small fraction of the total cellular transcriptome. This precludes the...

With the advancement of technology, we can generate and access large-scale, high dimensional and diverse genomics data, especially through single-cell RNA sequencing (scRNA-seq). However...

mRNA sequencing (RNA-seq) is a powerful tool that uses next-generation sequencing technologies to examine a cell’s transcriptome profile. This technology has a wide range of applications, from discovering novel transcripts and alternative splicing to analysing the transcriptome of samples in ...

A recent publication from researchers at the University of Kentucky explains the importance of identifying and understanding how differences...

Bacteria within the gut continuously adapt their gene expression to environmental conditions that are associated with diet, health, and disease. Noninvasive...

Sequencing costs currently prohibit the application of single-cell mRNA-seq to many biological and clinical analyses. Targeted single-cell mRNA-sequencing reduces sequencing costs by profiling reduced gene sets that capture biological information with a minimal number of genes. Caltech researchers have developed ...

A team of investigators from Texas Heart Institute, Texas Children’s Hospital and Baylor College of Medicine uncovered new insights into the mechanisms underlying the progression of congenital heart...