Novel biosensor uses DNA ‘barcodes’ to uncover disease signals in cells
RNA sequencing can read Detectron-generated DNA barcodes, enabling scalable detection of specific RNA signals associated with infection, gene activity and other cellular processes...
CellART extracts single-cell information from high-resolution spatial transcriptomics
Spatial transcriptomics allows researchers to measure gene activity while preserving information about where that activity occurs inside tissue. Newer technologies can reach very high spatial resolution, but they often face an important limitation, either they detect relatively few RNA ...
Cell2space restores spatial context to single-cell RNA sequencing data
Single-cell RNA sequencing can reveal which genes are active in individual cells, but the process of separating cells from tissue removes information about where those cells originally lived. That spatial information matters because cells behave differently depending on their ...
Urine test may improve bladder cancer diagnosis and guide treatment decisions
Researchers developed a urine test that detects bladder cancer, predicts which patients will benefit from immunotherapy versus chemotherapy, and can confirm whether treatment worked. simple urine test devised by researchers at Stanford Medicine and the VA Palo Alto Health ...
DeCoRE – a computational method to resolve RNA structural heterogeneity from RNA structure probing data by direct RNA sequencing
RNA molecules are flexible structures that can fold into different shapes. These shapes matter because RNA structure can influence how molecules are processed, recognized by proteins and used inside cells. Researchers at Tsinghua University have developed DeCoRE, short for ...
Tracing 700 million years of cell evolution
A new AI tool helps identify hidden similarities across distant species. Why do traditional genetic tools struggle to compare distant species? Scientists often compare cells using single-cell RNA sequencing, which shows which genes are active in each cell. When ...
How should biological replicates be handled in long-read RNA sequencing?
Long-read RNA sequencing allows researchers to read much larger portions of RNA molecules than traditional short-read methods. This makes it especially useful for identifying transcript isoforms, different versions of RNA produced from the same gene. As long-read RNA sequencing ...
RNA-Seq reveals a new way the developing heart controls its growth
Findings may ultimately have implications for heart repair after a heart attack Northwestern Medicine scientists have uncovered an unexpected part of the answer: lymphatic vessels, long known for transporting fluid and immune cells, also send signals to different cardiac ...
scFlowReport brings multiple single-cell RNA sequencing analyses into one workflow
Single-cell RNA sequencing allows researchers to measure gene activity in individual cells, making it possible to study how different cell types respond to disease, treatment or genetic changes. But generating the sequencing data is only the beginning. Researchers often ...
Long-read RNA sequencing reveals how neurons choose alternative RNA endings
A single gene can produce multiple RNA molecules with different structures. One important process behind this diversity is alternative polyadenylation, or APA, in which cells choose different locations near the end of an RNA transcript where the RNA is ...
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- BAP-seq – bioorthogonal masked acylating agents for proximity-dependent RNA labelling
- Single-cell RNA-seq of the rare virosphere reveals the native hosts of giant viruses in the marine environment
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