Publications

Are we sequencing too deep?

rna-seq

RNA-seq is increasingly used to study gene expression of various organisms. While it provides a great opportunity to explore genome-scale transcriptional patterns with tremendous depth, it comes with prohibitive costs. Establishing a minimal sequencing depth for required accuracy will guide ...

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CellNet – network biology applied to stem cell engineering

rna-seq

Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct conversions between differentiated cell lineages represent powerful approaches to engineer cells for research and regenerative medicine. A team led by researchers at Boston Children’s Hospital have developed CellNet, a ...

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