As a single organ, our skin is able to perform a broad repertoire of vital functions. Dermatology experts call for a reference guide to single-cell composition of normal human skin, which is still lacking...
Read More »The dawn of spatial omics
Just as single-cell sequencing has revolutionized many fields of biology, spatial “omics,” in which molecular parameters are measured in situ on intact tissue samples, is set to empower a new generation of scientific discoveries. A plethora of new...
Read More »The promise of single-cell rna sequencing to redefine the understanding of Crohn’s Disease fibrosis mechanisms
Crohn’s disease (CD) is a chronic inflammatory bowel disease with a high prevalence throughout the world. The development of Crohn’s-related fibrosis, which leads to strictures in the gastrointestinal tract...
Read More »Concepts and methods for transcriptome-wide prediction of chemical messenger RNA modifications with machine learning
The expanding field of epitranscriptomics might rival the epigenome in the diversity of biological processes impacted. In recent years, the development of new...
Read More »Applications of single-cell RNA sequencing in drug discovery and development
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods, together with associated computational tools and the growing availability of public data resources, are transforming drug discovery and development. New opportunities...
Read More »Methods and applications for single-cell and spatial multi-omics
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome from single cells is transforming our understanding of cell biology in health and disease. In less than a...
Read More »Improving diagnosis of genetic diseases with RNA sequencing
The use of next-generation sequencing (NGS) has simplified the diagnosis of human genetic disorders. Since the mapping of the human genome, scientists have been able to detect diseases even at a “single gene” level. While DNA-sequencing provides information about the ...
Read More »The evolution of single-cell RNA sequencing technology and application: progress and perspectives
As an emerging sequencing technology, single-cell RNA sequencing (scRNA-Seq) has become a powerful tool for describing cell subpopulation classification and cell heterogeneity by achieving high...
Read More »An introduction to nanopore sequencing
There has been significant progress made in the field of nanopore biosensor development and sequencing applications, which address previous limitations that restricted widespread nanopore...
Read More »An artificial intelligence-based non-small cell lung cancer transcriptome RNA-sequence analysis technology selection guide
The incidence and mortality rates of lung cancer are high worldwide, where non-small cell lung cancer (NSCLC) accounts for more than 85% of lung cancer cases. Recent non-small cell lung cancer research...
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