The Neuroscience Monoclonal Antibody Sequencing Initiative (NeuroMabSeq) is a concerted effort to determine and make publicly available hybridoma-derived sequences of monoclonal antibodies (mAbs) valuable to neuroscience research. Over 30 years of research and development efforts including those at the UC ...
Read More »NORMSEQ – a tool for evaluation, selection and visualization of RNA-Seq normalization methods
RNA-sequencing has become one of the most used high-throughput approaches to gain knowledge about the expression of all different RNA subpopulations. However, technical artifacts, either introduced during library preparation and/or data analysis, can influence the detected RNA expression levels. A ...
Read More »Interactive analysis of single-cell data using flexible workflows with the Single-Cell Toolkit 2
Analysis of single-cell RNA sequencing (scRNA-seq) data can reveal novel insights into the heterogeneity of complex biological systems. Many tools and...
Read More »RNAseqChef – a web-based integrative transcriptome analysis to automatically detect, integrate, and visualize differentially expressed genes and their biological functions
RNA sequencing (RNA-seq) is a powerful technique for understanding cellular state and dynamics. However, comprehensive transcriptomic characterization of multiple RNA-seq datasets is laborious without...
Read More »ExpressAnalyst – a unified platform for RNA-sequencing analysis in non-model species
The increasing application of RNA sequencing to study non-model species demands easy-to-use and efficient bioinformatics tools to help researchers quickly uncover biological and functional insights. Researchers at McGill University have developed...
Read More »QIAGEN launches RNA-seq Analysis portal with integrated Pathway Analysis
QIAGEN has launched the RNA-seq analysis portal (https://geneglobe.qiagen.com/us/analyze/rnaseq-analysis-and-biomarker-discovery-portal) which provides read-mapping and Ingenuity Pathway Analysis analysis to researchers looking for an easier way to go from Fastq file to biological insights. The portal is provided with the purchase of QIAseq ...
Read More »WASP – a versatile, web-accessible single cell RNA-Seq processing platform
The technology of single cell RNA sequencing (scRNA-seq) has gained massively in popularity as it allows unprecedented insights into cellular heterogeneity as well as identification and characterization of (sub-)cellular populations. Furthermore...
Read More »Biological misinterpretation of transcriptional signatures can undermine faithful alignment between clinical samples and preclinical data/models
Precise mechanism-based gene expression signatures (GES) have been developed in appropriate in vitro and in vivo model systems, to identify important cancer-related signaling processes. However, some GESs originally developed to represent specific disease processes, primarily with an epithelial cell focus, ...
Read More »aTAP – automated transcriptome analysis platform for processing RNA-seq data by de novo assembly
RNA-seq is a sequencing technique that uses next-generation sequencing (NGS) to explore and study the entire transcriptome of a biological sample...
Read More »PlaqView 2.0 – A comprehensive web portal for cardiovascular single-cell genomics
Single-cell RNA-seq (scRNA-seq) is a powerful genomics technology to interrogate the cellular composition and behaviors of complex systems. While the number of scRNA-seq datasets and available computational analysis tools have grown...
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