From Nature By Amber Dance
Circular RNAs are prevalent, mysterious and fascinating, but their study requires great care.
RNA can adopt many configurations in the cell (artist’s illustration).Credit: Christoph Burgsted/Science Photo Library/Getty
Over the past few decades, RNA’s place in biology has transformed from being a mere intermediate between DNA and protein to a fascinating molecule with diverse activities that go well beyond simple transcription of genetic information. Many of these RNAs fold up like molecular origami, but one of their most puzzling configurations is circular: molecules in which an unusual version of the standard RNA-splicing process folds the strand back on itself, creating a loop.
Once thought to be artefacts of splicing gone wrong, circular RNAs (circRNAs) are now known to be widespread across the tree of life. They’ve been implicated in conditions including cancer, cardiovascular disease and Alzheimer’s disease, and offer exciting possibilities as both therapeutic agents and biomarkers…
From Nature By Amber Dance
Circular RNAs are prevalent, mysterious and fascinating, but their study requires great care.
RNA can adopt many configurations in the cell (artist’s illustration).Credit: Christoph Burgsted/Science Photo Library/Getty
Over the past few decades, RNA’s place in biology has transformed from being a mere intermediate between DNA and protein to a fascinating molecule with diverse activities that go well beyond simple transcription of genetic information. Many of these RNAs fold up like molecular origami, but one of their most puzzling configurations is circular: molecules in which an unusual version of the standard RNA-splicing process folds the strand back on itself, creating a loop.
Once thought to be artefacts of splicing gone wrong, circular RNAs (circRNAs) are now known to be widespread across the tree of life. They’ve been implicated in conditions including cancer, cardiovascular disease and Alzheimer’s disease, and offer exciting possibilities as both therapeutic agents and biomarkers…
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From Nature By Amber Dance
Circular RNAs are prevalent, mysterious and fascinating, but their study requires great care.
RNA can adopt many configurations in the cell (artist’s illustration).Credit: Christoph Burgsted/Science Photo Library/Getty
Over the past few decades, RNA’s place in biology has transformed from being a mere intermediate between DNA and protein to a fascinating molecule with diverse activities that go well beyond simple transcription of genetic information. Many of these RNAs fold up like molecular origami, but one of their most puzzling configurations is circular: molecules in which an unusual version of the standard RNA-splicing process folds the strand back on itself, creating a loop.
Once thought to be artefacts of splicing gone wrong, circular RNAs (circRNAs) are now known to be widespread across the tree of life. They’ve been implicated in conditions including cancer, cardiovascular disease and Alzheimer’s disease, and offer exciting possibilities as both therapeutic agents and biomarkers…
Related Posts
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
RNA sequencing helps predict stem cell transplant benefit in pediatric AML
Protein ‘switch’ determines whether liposarcoma cells will become aggressive
Precursor tRNAs sense temperature changes: heat stress-induced capped pre-tRNAs suppress protein synthesis
Ketamine increases neuroplasticity in female mice but not in males
Somatic mutations linked to vascular damage in progeria
Scientists map dormant cancer cells’ hideouts, opening new targets for treatment
Soluble signals released by neighboring cells direct how the human kidney is built
Genetics influence how cancer arises – and how it evolves
RNA-based testing uncovers extraordinary diversity in mutations driving lung cancer
Study offers new insights into why ex-smokers remain at elevated risk of lung disease
Learning the grammar of gene regulation
New findings could transform new treatment for rare brain tumor astroblastoma
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