Columbia University: Two open post-doc positions for RNA-seq/spatial analyses in human brain disease

The Center for Translational and Computational Neuroimmunology at Columbia University in New York, NY (https://www.columbiactcn.org) is seeking two talented post-docs to lead analyses of bulk, single-cell, and spatial transcriptomics data from human brain samples in the context of brain disease.

Candidates will be analyzing single-nucleus and bulk RNA-sequencing data from human brain tissue covering multiple regions and neurodegenerative conditions, and relating findings to whole genome sequencing and proteomics. In addition, candidates will be involved in synthesizing spatial transcriptomics and protein expression data to localize cell types and changes in brain tissue.  The ultimate goal is to identify gene-gene and cell type interactions, and assess their dysregulation in Alzheimer’s, Parkinson’s, ALS, Multiple Sclerosis, and other human brain diseases. The candidate will be responsible for designing, leading, and carrying out integrative analyses of large molecular data sets, and developing innovative methods to integrate this with complementary clinical and pathological data.

Successful candidates will be part of an integrated team of seven principal investigators (with experimental and computational expertise), data scientists, cellular biologists, human immunologists, and clinician scientists who come together to perform team-based projects, with each post-doctoral researcher leading his or her own project. These positions thus offer the opportunity to work with researchers at Columbia University, the New York Genome Center, and the Broad Institute of MIT and Harvard University. These include multiple opportunities to contribute to multiple ongoing national and international collaborative projects.

Requirements: Ph.D. in computational biology, bioinformatics, computational neuroscience, applied mathematics, statistics, biostatistics, physics, computer science, or related area. Ph.D. in biology or neuroscience with programming experience is also acceptable.

Application and inquiries should be submitted by e-mail to Vilas Menon (vm2545@cumc.columbia.edu). Along with your CV, please include a cover letter describing previous research, research interests, and future goals. Please provide contact details for 3 references.