Plowing through Transcriptional Variations by Harnessing the Powerful Next-Gen Technique
Sequencing of RNA molecules, like the one pictured here, is a powerful laboratory discovery tool and has the potential to play a major role in clinical diagnostics. [petarg/Shutterstock]
Advances in genomics over the past several years have had a profound impact on our grasp of molecular biology and genetics. In the laboratory, next-generation sequencing (NGS) has been applied to identifying novel genomes for an array of organisms, DNA resequencing, transcriptome sequencing, and epigenetics. Within clinical settings, NGS is beginning to cut its teeth and is being rapidly embraced as an invaluable diagnostic tool. Specifically, the ability to interpret the genetic mechanisms that underlie variations in human gene expression through the direct analysis of the transcriptome makes RNA sequencing (RNA-Seq) an attractive method to clinical diagnosticians. “RNA-Seq provides a very specific and sensitive genomic signature that can be useful in many clinical situations,” said Gary Schroth, Ph.D., distinguished scientist at Illumina.
RNA-Seq examines the dynamic nature of the cell’s transcriptome, the portion of genome that is actively transcribed into RNA molecules. While DNA remains relatively unchanged throughout an individual’s lifespan, RNA, in the form of transcriptional elements, can vary dramatically due to influences on epigenetic regulators, alternative spliced variants, or post-transcriptional modifications. (read more…)
Plowing through Transcriptional Variations by Harnessing the Powerful Next-Gen Technique
Sequencing of RNA molecules, like the one pictured here, is a powerful laboratory discovery tool and has the potential to play a major role in clinical diagnostics. [petarg/Shutterstock]
Advances in genomics over the past several years have had a profound impact on our grasp of molecular biology and genetics. In the laboratory, next-generation sequencing (NGS) has been applied to identifying novel genomes for an array of organisms, DNA resequencing, transcriptome sequencing, and epigenetics. Within clinical settings, NGS is beginning to cut its teeth and is being rapidly embraced as an invaluable diagnostic tool. Specifically, the ability to interpret the genetic mechanisms that underlie variations in human gene expression through the direct analysis of the transcriptome makes RNA sequencing (RNA-Seq) an attractive method to clinical diagnosticians. “RNA-Seq provides a very specific and sensitive genomic signature that can be useful in many clinical situations,” said Gary Schroth, Ph.D., distinguished scientist at Illumina.
RNA-Seq examines the dynamic nature of the cell’s transcriptome, the portion of genome that is actively transcribed into RNA molecules. While DNA remains relatively unchanged throughout an individual’s lifespan, RNA, in the form of transcriptional elements, can vary dramatically due to influences on epigenetic regulators, alternative spliced variants, or post-transcriptional modifications. (read more…)
from Genetic Engineering News by Jeffrey S. Buguliskis, Ph.D.
Plowing through Transcriptional Variations by Harnessing the Powerful Next-Gen Technique
Sequencing of RNA molecules, like the one pictured here, is a powerful laboratory discovery tool and has the potential to play a major role in clinical diagnostics. [petarg/Shutterstock]
RNA-Seq examines the dynamic nature of the cell’s transcriptome, the portion of genome that is actively transcribed into RNA molecules. While DNA remains relatively unchanged throughout an individual’s lifespan, RNA, in the form of transcriptional elements, can vary dramatically due to influences on epigenetic regulators, alternative spliced variants, or post-transcriptional modifications. (read more…)
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from Genetic Engineering News by Jeffrey S. Buguliskis, Ph.D.
Plowing through Transcriptional Variations by Harnessing the Powerful Next-Gen Technique
Sequencing of RNA molecules, like the one pictured here, is a powerful laboratory discovery tool and has the potential to play a major role in clinical diagnostics. [petarg/Shutterstock]
RNA-Seq examines the dynamic nature of the cell’s transcriptome, the portion of genome that is actively transcribed into RNA molecules. While DNA remains relatively unchanged throughout an individual’s lifespan, RNA, in the form of transcriptional elements, can vary dramatically due to influences on epigenetic regulators, alternative spliced variants, or post-transcriptional modifications. (read more…)
Related Posts
An anti-senescence gene may fight spinal disc deterioration
Scientists identify the neuroblastoma cells that signal poor outcomes
Urine test may improve bladder cancer diagnosis and guide treatment decisions
Tracing 700 million years of cell evolution
RNA-Seq reveals a new way the developing heart controls its growth
The Human RNome Project Consortium seeks to publish first-ever complete sequence of the body’s RNA
Unmasking “zombie cells” in aging tissue with an AI-powered barcode
RNA variant imaging for cancer diagnosis
Autism-risk mutations reveal two opposing patterns of brain gene activity
Avoiding a sticky situation: how cells stop messenger RNAs from clumping together
RNA Sequencing identifies new tick-borne virus that causes flu-like illness
Worm’s radical transformation shows metamorphosis can change the functions of cells
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
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