Decoding cancer transcriptomes using public RNA-Seq data

Speaker: Dr. Pieter Mestdagh, Ghent University / Biogazelle, Belgium
Event: Biogazelle sponsored RNA-sequencing mini-symposium (Ghent – Belgium, Jan. 14, 2015)

Genome-wide studies have shown that our genome is pervasively transcribed, producing a complex pool of coding and non-coding transcripts that shape the cancer transcriptome. Long non-coding RNAs or lncRNAs dominate the non-coding transcriptome and are emerging as key regulatory factors in human disease and development. Through re-analysis of RNA-sequencing data from 8000 cancer patients across 24 cancer types (The Cancer Genome Atlas), we define a PAN-cancer lncRNA landscape, revealing insights in cancer-specific lncRNAs with therapeutic and diagnostic potential.