from Genetic Engineering News by Vicki Glaser
Next-Generation Sequencing Is Increasingly Making Headway in Clinical Medicine for Diagnostic and Prognostic Purposes
It’s early days, but next-generation sequencing (NGS) is increasingly making headway in clinical medicine for diagnostic and prognostic purposes, for guiding disease management, and for monitoring treatment response.
Progress is particularly striking in cancer, where an NGS technology called RNA sequencing (RNA-Seq) is being used to sequence the transcriptome and decode the mechanisms and pathways by which noncoding RNA regulates gene expression. By explicating the role of noncoding RNA in tumorigenesis, RNA-Seq is creating new opportunities for biomarker and drug target discovery.
Emerging data reveal the complexity of the various types of noncoding RNA elements—microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs)—and how they function and interact to maintain finely tuned post-transcriptional regulatory control over transcript abundance. As studies have shown, changes in the levels of miRNAs, for example, can lead to transcript dysregulation associated with cancer.
(read more…)
from Genetic Engineering News by Vicki Glaser
Next-Generation Sequencing Is Increasingly Making Headway in Clinical Medicine for Diagnostic and Prognostic Purposes
It’s early days, but next-generation sequencing (NGS) is increasingly making headway in clinical medicine for diagnostic and prognostic purposes, for guiding disease management, and for monitoring treatment response.
Progress is particularly striking in cancer, where an NGS technology called RNA sequencing (RNA-Seq) is being used to sequence the transcriptome and decode the mechanisms and pathways by which noncoding RNA regulates gene expression. By explicating the role of noncoding RNA in tumorigenesis, RNA-Seq is creating new opportunities for biomarker and drug target discovery.
Emerging data reveal the complexity of the various types of noncoding RNA elements—microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs)—and how they function and interact to maintain finely tuned post-transcriptional regulatory control over transcript abundance. As studies have shown, changes in the levels of miRNAs, for example, can lead to transcript dysregulation associated with cancer.
(read more…)
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from Genetic Engineering News by Vicki Glaser
Next-Generation Sequencing Is Increasingly Making Headway in Clinical Medicine for Diagnostic and Prognostic Purposes
It’s early days, but next-generation sequencing (NGS) is increasingly making headway in clinical medicine for diagnostic and prognostic purposes, for guiding disease management, and for monitoring treatment response.
Progress is particularly striking in cancer, where an NGS technology called RNA sequencing (RNA-Seq) is being used to sequence the transcriptome and decode the mechanisms and pathways by which noncoding RNA regulates gene expression. By explicating the role of noncoding RNA in tumorigenesis, RNA-Seq is creating new opportunities for biomarker and drug target discovery.
Emerging data reveal the complexity of the various types of noncoding RNA elements—microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs)—and how they function and interact to maintain finely tuned post-transcriptional regulatory control over transcript abundance. As studies have shown, changes in the levels of miRNAs, for example, can lead to transcript dysregulation associated with cancer.
(read more…)
Related Posts
Overlooked DNA regions surrounding ‘microexons’ hold missing pieces of autism’s genetic puzzle
An anti-senescence gene may fight spinal disc deterioration
Scientists identify the neuroblastoma cells that signal poor outcomes
Urine test may improve bladder cancer diagnosis and guide treatment decisions
Tracing 700 million years of cell evolution
RNA-Seq reveals a new way the developing heart controls its growth
The Human RNome Project Consortium seeks to publish first-ever complete sequence of the body’s RNA
Unmasking “zombie cells” in aging tissue with an AI-powered barcode
RNA variant imaging for cancer diagnosis
Autism-risk mutations reveal two opposing patterns of brain gene activity
Avoiding a sticky situation: how cells stop messenger RNAs from clumping together
RNA Sequencing identifies new tick-borne virus that causes flu-like illness
Worm’s radical transformation shows metamorphosis can change the functions of cells
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
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