Single-cell analysis can help tease apart heterogeneity in complex cell populations, distinguishing cell types and revealing dynamic cell states. The 10x Genomics Chromium Single Cell Multiome ATAC + Gene Expression prepares sequencing-ready libraries to simultaneously profile gene expression and chromatin accessibility from the same cell.
Figure 1: Multiomics approach can combine ATAC sequencing and gene expression profiling.
Combining ATAC sequencing and gene expression profiling has become more affordable and accessible on new sequencing platforms. Illumina NovaSeq X enable more in-depth sequencing and easier onboard informatics, allowing more information per sample. Illumina has recently published NovaSeq X sequencing data for single cell ATAC and gene expression profiling, in collaboration with 10X Genomics.
Figure 2: workflow for preparing 10x Genomics Multiome libraries and sequencing them on Illumina platforms.
To explore the data, check out Illumina’s new blog post: https://developer.illumina.com/news-updates/10x-genomics-chromium-single-cell-multiome-atac-gene-expression-data-on-novaseq-x-series-now-available-on-basespace-sequence-hub