Featured RNA-Seq Job – Bioinformatician – WormBase

The Parasite genomics team at the Wellcome Trust Sanger Institute are seeking a talented Bioinformatician to work on WormBase ParaSite (parasite.wormbase.org), a portal for parasitic worm genomics. Parasitic worms are responsible for more than one billion human infections globally and have a devastating impact on livestock and agriculture. WormBase-ParaSite facilitates new approaches to the study and control of parasitic worms by integrating, analysing and displaying genomic data for hundreds of species.

You will work on a range of data analysis, data integration and community-engagement activities for WormBase ParaSite, and will also actively participate in the exciting next phase of development for the resource. The main areas of focus will be:

  • Customisation and deployment of annotation pipelines for parasitic worm genomes
  • Analysis, curation and integration of large-scale genomics data sets (e.g. studies of gene expression and genomic variation)
  • Development of the resource to support  drug target identification
  • Community engagement, including presentations and tutorials at workshops and conferences

WormBase ParaSite is a sister project to the well-known WormBase (www.wormbase.org) and Ensembl (www.ensembl.org) projects. As well as working with genome scientists within the Parasite genomics team, you will also spend time working with WormBase and Ensembl staff at the neighbouring European Bioinformatics Institute (EMBL-EBI).

Essential Skills

  • Good programming/ scripting skills (e.g. Perl or Python)
  • Proficiency in Unix/Linux operating system
  • Experience using relational database systems (MySQL or Postgres)
  • Strong grounding in genome biology
  • Excellent communication skills
  • Attention to detail

Ideal Skills

  • Bioinformatics experience at Masters or PhD level
  • Experience analysing functional genomics experiments (especially RNASeq)
  • Experience with software version control systems
  • Knowledge of parasitology, preferably helminths
  • Experience with genome annotation methodologies and pipelines
  • Familiarity with the Ensembl Application Programming Interface
  • Previous annotation/curation experience

Other information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Closing date 1st September 2017

Applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the closing date, as interviews will take place on an on-going basis.

Please include a covering letter and CV with your application.

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