Featured RNA-Seq Job – Bioinformatics Scientist

Organization Neurona Therapeutics
Position Bioinformatics Scientist
Location San Francisco Bay Area
Manager Senior Scientist – Discovery
Status Exempt

Overview:

Neurona Therapeutics is an early stage biotechnology company based in South San Francisco focused on the development of neuronal cell-based therapies for neurological diseases. Our ideal candidate is a self-motivated individual who has a passion for scientific research. This is a fantastic opportunity to join a small team, work on transformative science, and take part in building an exciting, science-driven company.

Position Summary:

As a bioinformatics scientist, you will collaborate with discovery and preclinical scientists and play a leading role in building a bioinformatics pipeline that will support biomarker discovery, enable deep characterization of existing products, and fuel novel product development.

Key Responsibilities:

  • Develop and implement in house bioinformatics pipeline for single cell and single nucleus RNA sequencing data
  • Collaborate with multidisciplinary teams to conceptualize, execute and analyze experiments in support of internal studies and external collaboration
  • Implement standard data analysis, stay up to date with relevant literature, integrate novel analytic approaches
  • Build an accessible database and implement visualization platforms to facilitate internal data mining
  • Communicate extensively across department
  • Maintain detailed records up to industry standard
  • Prepare results for internal presentations, grant and patent applications, scientific publications, and FDA filings

Requirements:

  • PhD degree in Bioinformatics, Computer Science, Computational Biology, Genetics or related field
  • 5+ years of experience and demonstrated track record, including research publications, working with NGS pipelines
  • Hands-on with single-cell RNA-sequencing data generation, analysis and visualization
  • Experience in sequence alignment, mapping, annotation
  • Proficiency with R and ability to implement open source packages
  • Ability to script in Python, Perl or similar language
  • Proficiency with Microsoft Excel or similar software (basic functions, no macro experience required)
  • Competency to read and incorporate new published approaches for analysis
  • Experience with commonly used visualization strategies, including from ggplot and Morpheus
  • Willingness to expand skill set and contribute to emerging needs in a highly dynamic start-up environment
  • High integrity, great organization and ability to multitask while working within fast-paced timelines
  • Excellent written and verbal communication skills
  • Strong team player and problem-solver
  • Able to work independently and take initiative to improve work processes, develop innovative scientific methodologies and approaches to enhance research productivity

Preferred Qualifications:

  • Familiarity with 10X Drop Seq pipeline
  • Experience with single nucleus RNA-sequencing is a plus
  • General -omics expertise: genomics, epigenomics, chromatin dynamics
  • Sterile cell culture expertise
  • Familiarity with in vitro directed differentiation paradigms from pluripotent stem cells (especially along the neuronal lineage), and molecular characterization of derived cell types
  • Basic knowledge of neuroscience and developmental biology is a plus
  • Proficient in candidate marker expression assays: ICC, qRT-PCR, ISH, Flow
  • Neurona Therapeutics is proud to be an equal opportunity employer and will consider all qualified applicants for employment.
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