Featured RNA-Seq Job – Computational Biologist

Morgridge InstituteThe Opportunity:

The Morgridge Institute for Research seeks a Computational Biologist to provide bioinformatics support to researchers studying gene expression, epigenomics, proteomics and transcriptional regulation in embryonic stem cells and their differentiated derivatives. This position is part of the bioinformatics team within stem cell pioneer James Thomson’s Regenerative Biology Laboratory of the Morgridge Institute for Research. The following are core responsibilities of this position:

  • Provide analysis of RNA-Seq, ChIP-Seq and other datatypes, including primary analysis of mapping sequence reads, as well as secondary analysis (such as gene expression, peak finding, correlation analysis, and data mining)
  • Develop data analysis pipelines for all aspects of next-generation sequencing (NGS) data analysis as well as provide specialized reports, figures, tables, and graphs of NGS and other data output for wet lab scientists and other team members
  • Maintain accurate and detailed records of work and present experimental results in lab meetings, local and national scientific meetings and journal manuscripts
  • Develop and maintain methods for analyzing NGS data in the context of other sources of data such as gene expression, DNA/RNA/protein interaction, chromatin modification, pathway, motif, Gene Ontology, and other public and proprietary sources of data
  • Investigate, implement, and integrate new algorithms for downstream analysis of NGS data
  • Design, implement, test, install, and maintain systems to store, manipulate, collect, analyze, annotate, visualize, and manage biological information for the Regenerative Biology team

Candidate Requirements:

We are seeking candidates who have a master’s degree (or a bachelor’s degree plus equivalent experience and education) in computer science, mathematics, bioinformatics, or biological sciences, Ph.D is preferred. Strong systems design and programming skills are required as demonstrated by at least three years of experience in programming with C, C++, Java, Perl and/or Python as well as at least one year of experience with statistical programming with R, MatLab or S-PLUS. Bioinformatics experience along with familiarity with RDBMS (MySQL, Oracle, MSSQL, or PostGres) and environments/methodology including source code control is required. Experience with Make and CVS is preferred. Candidates also must exhibit strong oral and written communication skills as well as excellent interpersonal skills. Experience with NGS analysis, statistical analysis of genome-wide data and/or scientific/AI programming skills including HMMs, data mining, neural networks, algorithm development is preferred.

The Organization:

The Morgridge Institute for Research benefits the University of Wisconsin–Madison and the citizens of Wisconsin by advancing breakthrough biomedical discoveries to solve important global health challenges and by educating the public about science. We do this as a private, nonprofit organization by developing and using high-impact computational, biological and physical research tools in collaborations with the university that benefit from our unique public-private partnership and organizational strengths.

At the Morgridge Institute our current research focuses on Regenerative Biology, Virology, Medical Devices and High Throughput Computation/Bioinformatics. The Morgridge Institute for Research is the private side of the Wisconsin Institutes for Discovery, a public-private initiative that leverages the best features of a great public university with the flexibility and resources of an independent world-class private research institute. Our state-of-the-art facility, named Lab of the Year by R&D Magazine, not only houses research, but also includes extensive public spaces in our Town Center that welcomes all with food, interactive displays, ongoing activities, hands-on learning labs, events and meeting spaces. For additional information, please visit: http://discovery.wisc.edu/morgridge .

To apply: Qualified individuals interested in this opportunity are required to submit a cover letter and resume via the online career portal within the career section at:http://discovery.wisc.edu/home/morgridge/careers/careers.cmsx.

The Morgridge Institute for Research is an equal opportunity employer.