Featured RNA-Seq Job – Senior Research Scientist, Technology Development

Tracking Code 611 – 105

Job Description

The Technology Development Lab at NYGC supports cutting-edge research through scientific collaboration, focusing on innovative single-cell and spatial genomic assay and tool development, optimization and application.The Senior Research Scientist in the Technology Development Lab will work with a highly motivated team towards the development and implementation of novel strategies for genomics research. The ideal candidate will have a well-established background in molecular or cell biology with applicable experience in single-cell or spatial multi-omics technologies. Additional experience in imaging technologies or NGS-based platforms is preferred. Strong interpersonal and communication skills are required, as this role will work on an interdisciplinary team and actively collaborate across multiple functional groups to develop and implement innovative new technologies into production. The ability to thrive in a fast-paced and shifting environment is essential. This position will report to the Associate Director of Technology Development and be responsible for supervision of junior staff.

Key Responsibilities include (but are not limited to):

  • Lead implementation of single-cell, multi-modal and spatial methods, developing robust, scalable assays for application to collaborative and production research projects;
  • Collaborate closely with colleagues in the Technology Innovation, Technology Development,  Production Lab, and Computational Biology teams, facilitating knowledge transfer and cross-functional coordination;
  • Analyze, interpret and report high-quality research through journal articles, posters and impactful presentations to colleagues including senior leadership, external collaborators and at scientific conferences;
  • Develop and implement novel strategies to prepare samples and sequencing libraries at scale for methods that capture single-cell-omics and spatially-resolved data;
  • Independently plan, design and execute experiments to support collaborative projects, grant funded research and internal assay development, optimization and troubleshooting efforts, managing various aspects of a project;
  • Contribute to existing lab projects and improving current laboratory methods;
  • Contribute to writing and editing grant applications and providing dedicated effort to support funded work;
  • Collaborate with internal and external research groups to offer relevant expertise and guidance with project design and to conduct experiments using cutting-edge techniques in support of project goals;
  • Maintain extensive knowledge of the current scientific literature and be a source of knowledge for the team and the Center in applying molecular biology tools to solve specific research questions;
  • Actively participate in lab meetings, sharing and expanding the knowledge of the team and obtaining information relevant to the team’s goals; and,
  • Supervise junior staff including mentoring, coaching, training, prioritization and oversight of day-to-day activities.

Required Skills

  • Relevant PhD degree with experience in single-cell or spatial biology, or BSc/MSc with significant equivalent experience;
  • Experience working with cell-based assays or spatial biology platforms;
  • Extensive knowledge of and experience with modern molecular biology tools including prior experience working with single-cell suspensions and/or tissue samples, such as cell sorting, nuclei isolation, dissociation, sectioning, staining, or imaging;
  • Excellent collaboration, interpersonal and communication skills and ability to effectively work as part of a team;
  • Ability to work independently with minimal supervision and lead junior staff effectively;
  • Exceptional organizational, time management and critical thinking skills;
  • Proven attention to detail with excellent planning and experimental design skills;
  • Excellent analytical and project management skills and ability to prioritize and multitask;
  • Strong computational skills highly preferred.

Required Experience


  • Technical and Professional Skills: Consistently demonstrates skills and knowledge relevant for current role; strives to expand the depth and breadth of technical and professional skills; works with a high level of integrity; exhibits focus and discipline; appropriately prioritizes, manages expectations and delivers on commitments.
  • Collaborative & Communicative: Models collaboration and teamwork; brings out the best in others; effectively works with all levels, internally and externally; respects and embraces diversity of perspective; communicates clearly and listens carefully; uses good judgment as to what to communicate and when to do so.
  • Adaptable & Innovative: Adaptable and embraces change; develops new insights and pursues improvements and efficiency; fosters exchange of new ideas and willing to challenge the status quo; takes initiative and is solution-oriented; engages in work with passion and curiosity.
  • Leader and Manager: Attracts, develops and retains diverse talent to achieve outstanding results; encourages professional development, coaches and regularly communicates expectations and feedback; aligns and inspires efforts toward our mission; translates

About the New York Genome Center

The New York Genome Center (NYGC) is an independent, nonprofit, academic research organization dedicated to advancing genomic research. NYGC scientists and staff are furthering new approaches to diagnosing and treating neurological diseases and cancer through their unique capabilities in whole genome sequencing, RNA sequencing, state-of-the art analytics, and the development of genomic tools. NYGC concentrates specifically on disease-based research in the following areas: neuropsychiatric disease (autism, schizophrenia, bipolar); neurodegenerative disease (ALS, Alzheimer’s, Parkinson’s, Huntington’s), and cancer.

Located in Lower Manhattan, the New York Genome Center was founded by and remains closely affiliated with the leading academic medical centers and research universities in the New York region, engaging in research projects with and for these institutions. Essential to our collaborative work is an outstanding faculty, whose members typically hold a joint appointment at NYGC and a partner university. They support our scientific mission by conducting independent research in areas of mutual interest to us and the wider scientific community.

Please note: We care greatly about our employees’ wellbeing, so NYGC has moved to a fully COVID-19 vaccinated work environment. You must be vaccinated against COVID-19 to work at NYGC, even if you are working partially remotely. If you are selected to interview for this role, we will explain our vaccination policy (including medical and religious exemptions) and ensure you are comfortable moving forward with further interviews.

Equal Opportunity

Diversity, equity, and inclusion are central to NYGC’s core mission. We strive to create a workplace environment that is welcoming and fair to all regardless of race, ethnicity, gender, sexual orientation, physical ability, or religion. We believe that when people of various backgrounds, life experiences, and perspectives work together in an inclusive and equitable environment we gain new and valuable perspectives that otherwise would have been missed. Valuing and supporting all NYGC employees as individuals while helping them realize their full potential is critical to promoting greater collaboration, innovation, and discovery – fostering a sense of belonging for our greatest strength, our people. We recognize that there is still work to be done that will require sustained commitment from the entire organization.

The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, creed, color, gender, religion, national origin, sexual orientation, age, disability, genetic predisposition or carrier status, protected veteran or military status, domestic violence victim status, partnership status, caregiver status, alienage or citizenship status, marital status, or any other characteristic protected by applicable law. NYGC takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

FLSA Status – Exempt
This position is eligible for visa sponsorship and relocation assistance.

Job Location – New York, New York, United States

Position Type – Full-Time/Regular


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