RNA-Seq Blog Transcriptome Research & Industry News
Gene fusion is a chromosomal rearrangement event which plays a significant role in cancer due to the oncogenic potential of the chimeric protein generated through fusions. The chimeric protein produced as a result of fusion of genes often possesses oncogenic properties and such genes usually act as driver genes in cancer.
At present many databases and research articles are available in public domain where one can find information about fusion genes. However the information available are scattered and highly heterogeneous. We have recently developed a web platform, FusionHub where we provide a search engine, FusionSearch, that integrates 25 such information resources and allow user to carry out batch annotation of fusion genes in a seamless way. The platform additionally allows users to visualize gene fusion events. It provides three ways of visualizing fusion events: circular view, domain architecture view and network view. Design of potential siRNA molecules through ensemble method is another utility integrated in FusionHub that could aid in siRNA-based targeted therapy.
These three features such as gene fusion annotation, visualization and siRNA designing makes FusionHub a unified platform for carrying our most gene fusion analysis.
It is free to use. It is published in PLoS ONE 13(5): e0196588
