From The Scientist by Deanna MacNeil, PhD
In work published in iScience, a research team led by molecular biologist Alejandro Sánchez Alvarado at the Stowers Institute for Medical Research turned to single-cell RNA sequencing to identify the targets involved in positional memory.2 They investigated how amputation position informs regenerating tailfins in African killifish (Nothobranchius furzeri) and identified a cell state in the basal epidermis that is transiently amplified based on amputation distance from the body. They also found extracellular matrix (ECM) components that govern regenerative capacity, and evidence that growth rate can be uncoupled from amputation position.
From The Scientist by Deanna MacNeil, PhD
In work published in iScience, a research team led by molecular biologist Alejandro Sánchez Alvarado at the Stowers Institute for Medical Research turned to single-cell RNA sequencing to identify the targets involved in positional memory.2 They investigated how amputation position informs regenerating tailfins in African killifish (Nothobranchius furzeri) and identified a cell state in the basal epidermis that is transiently amplified based on amputation distance from the body. They also found extracellular matrix (ECM) components that govern regenerative capacity, and evidence that growth rate can be uncoupled from amputation position.
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From The Scientist by Deanna MacNeil, PhD
In work published in iScience, a research team led by molecular biologist Alejandro Sánchez Alvarado at the Stowers Institute for Medical Research turned to single-cell RNA sequencing to identify the targets involved in positional memory.2 They investigated how amputation position informs regenerating tailfins in African killifish (Nothobranchius furzeri) and identified a cell state in the basal epidermis that is transiently amplified based on amputation distance from the body. They also found extracellular matrix (ECM) components that govern regenerative capacity, and evidence that growth rate can be uncoupled from amputation position.
Related Posts
Small RNA sequencing reveals regulatory roles for sdRNAs in acute myeloid leukemia
POND-seq enables non-destructive RNA sequencing in living cells
Worm’s radical transformation shows metamorphosis can change the functions of cells
New method allows scientists to follow gene activity over time in the same cells
Single-cell and single-embryo RNA sequencing
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Deep learning improves microRNA target prediction from sequence
Atlas of the brain’s striatum could guide researchers to new drug treatments
scLS – a computationally efficient differentially expressed gene detection algorithm
Spatial mapping of RNA turnover kinetics in the mouse brain
Immune cells offer insights on billion-dollar virus
SPIDER improves spatial transcriptomics data using single-cell RNA sequencing
Ultrafast and reference-free sequence discovery in single-cell data
ARCADIA combines RNA sequencing and spatial proteomics to reveal how tissue location shapes cell behavior
An end-to-end computational framework for “Record-seq” transcriptional recording data
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
ExoShorkie – predicting RNA-seq coverage of exogenous genomes in yeast by transfer learning
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Bonsai reconstructs tree representations for distortion-free visualization and exploration of high-dimensional data
MiRQuery – a user-friendly web app for the interactive analysis and visualization of microRNA sequencing data
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