from CancerTherapyAdvisor by Jason Hoffman, PharmD, RPh –
CHICAGO —Single-cell RNA-sequencing can resolve the heterogeneity of both malignant and non-malignant tumor components, according to findings presented at the 2016 American Society of Clinical Oncology (ASCO) Annual Meeting.
Current profiling technologies provide only average signals that do not reflect the intrinsic genetic phenotypic variability in heterogeneity of malignant and non-malignant cells, explained Benjamin Izar, MD, PhD, of the Broad/DFCI Center for Cancer Precision Medicine in Boston, Massachusetts. Researchers sought to apply single-cell RNA-sequencing to 4645 single cells, profiling malignant, immune, and stromal cells isolated from 19 newly-procured melanomas. (read more…)
[box type=”shadow” align=”alignleft” ]Izar B, Tirosh I, Prakadan S, Wadsworth M, Rotem A, Trombetta J, et al. (2016)
Implementation of single-cell genomics as a translational tool in patients with metastatic melanoma.
J Clin Oncol 34 (suppl; abstr 11503).[/fusion_text][/fusion_builder_column_inner][/fusion_builder_row_inner][/fusion_builder_column]
from CancerTherapyAdvisor by Jason Hoffman, PharmD, RPh –
CHICAGO —Single-cell RNA-sequencing can resolve the heterogeneity of both malignant and non-malignant tumor components, according to findings presented at the 2016 American Society of Clinical Oncology (ASCO) Annual Meeting.
Current profiling technologies provide only average signals that do not reflect the intrinsic genetic phenotypic variability in heterogeneity of malignant and non-malignant cells, explained Benjamin Izar, MD, PhD, of the Broad/DFCI Center for Cancer Precision Medicine in Boston, Massachusetts. Researchers sought to apply single-cell RNA-sequencing to 4645 single cells, profiling malignant, immune, and stromal cells isolated from 19 newly-procured melanomas. (read more…)
[box type=”shadow” align=”alignleft” ]Izar B, Tirosh I, Prakadan S, Wadsworth M, Rotem A, Trombetta J, et al. (2016) Implementation of single-cell genomics as a translational tool in patients with metastatic melanoma. J Clin Oncol 34 (suppl; abstr 11503).[/fusion_text][/fusion_builder_column_inner][/fusion_builder_row_inner][/fusion_builder_column]Related Posts
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from CancerTherapyAdvisor by Jason Hoffman, PharmD, RPh –
CHICAGO —Single-cell RNA-sequencing can resolve the heterogeneity of both malignant and non-malignant tumor components, according to findings presented at the 2016 American Society of Clinical Oncology (ASCO) Annual Meeting.
Current profiling technologies provide only average signals that do not reflect the intrinsic genetic phenotypic variability in heterogeneity of malignant and non-malignant cells, explained Benjamin Izar, MD, PhD, of the Broad/DFCI Center for Cancer Precision Medicine in Boston, Massachusetts. Researchers sought to apply single-cell RNA-sequencing to 4645 single cells, profiling malignant, immune, and stromal cells isolated from 19 newly-procured melanomas. (read more…)
[box type=”shadow” align=”alignleft” ]Izar B, Tirosh I, Prakadan S, Wadsworth M, Rotem A, Trombetta J, et al. (2016) Implementation of single-cell genomics as a translational tool in patients with metastatic melanoma. J Clin Oncol 34 (suppl; abstr 11503).[/fusion_text][/fusion_builder_column_inner][/fusion_builder_row_inner][/fusion_builder_column]Related Posts
RNA Sequencing identifies new tick-borne virus that causes flu-like illness
Worm’s radical transformation shows metamorphosis can change the functions of cells
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
RNA sequencing helps predict stem cell transplant benefit in pediatric AML
Protein ‘switch’ determines whether liposarcoma cells will become aggressive
Precursor tRNAs sense temperature changes: heat stress-induced capped pre-tRNAs suppress protein synthesis
Ketamine increases neuroplasticity in female mice but not in males
Somatic mutations linked to vascular damage in progeria
Scientists map dormant cancer cells’ hideouts, opening new targets for treatment
Soluble signals released by neighboring cells direct how the human kidney is built
Genetics influence how cancer arises – and how it evolves
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Study offers new insights into why ex-smokers remain at elevated risk of lung disease
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