Living the single life

From Laboratory News by Vincent Croset, Iver Nordentoft & Nadia Shakir

Scientists are increasingly taking advantage of microfluidic technology for single cell applications to understand individual cells and their role in health and immunity. Here we look at latest advances in the technology and some examples of microfluidic approaches to single cell research…

Understanding how single cells within an individual person, tissue or organ differ throughout development or as a result of disease has great potential to help advance personalised medicine.

Since high throughput single cell applications based on microfluidic droplet technology came to the fore in 2015, researchers have taken advantage of single cell RNA-seq (scRNA-seq) methods to increase their knowledge of cell development, immunology and immunotherapy, as well as tumour heterogeneity, lineage analysis and clonal evolution.

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