from SFARI.org by Michael Talkowski, James Gusella
Measuring RNA expression from individual genes provides one route to novel insights in understanding human disorders such as autism. For example, it may reveal the impact of a genetic mutation on the gene itself or its indirect consequences on the expression of other genes.
Patterns of RNA expression can also help to define genetic networks and to reveal the effects of perturbing these systems. Applying network approaches over time can also inform us about the disorder and how it progresses.
The most appropriate tissue in which to study gene expression and networks is a frequently debated topic. As powerful new technologies generate seemingly endless streams of data, it has become clear that there is no single answer. The best source from which to draw meaningful conclusions about gene expression depends on the specific question being asked. And generalizing from one tissue to another inevitably involves appropriate caveats that must temper interpretation.
(read more…)
from SFARI.org by Michael Talkowski, James Gusella
Measuring RNA expression from individual genes provides one route to novel insights in understanding human disorders such as autism. For example, it may reveal the impact of a genetic mutation on the gene itself or its indirect consequences on the expression of other genes.
Patterns of RNA expression can also help to define genetic networks and to reveal the effects of perturbing these systems. Applying network approaches over time can also inform us about the disorder and how it progresses.
The most appropriate tissue in which to study gene expression and networks is a frequently debated topic. As powerful new technologies generate seemingly endless streams of data, it has become clear that there is no single answer. The best source from which to draw meaningful conclusions about gene expression depends on the specific question being asked. And generalizing from one tissue to another inevitably involves appropriate caveats that must temper interpretation.
(read more…)
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from SFARI.org by Michael Talkowski, James Gusella
Measuring RNA expression from individual genes provides one route to novel insights in understanding human disorders such as autism. For example, it may reveal the impact of a genetic mutation on the gene itself or its indirect consequences on the expression of other genes.
Patterns of RNA expression can also help to define genetic networks and to reveal the effects of perturbing these systems. Applying network approaches over time can also inform us about the disorder and how it progresses.
The most appropriate tissue in which to study gene expression and networks is a frequently debated topic. As powerful new technologies generate seemingly endless streams of data, it has become clear that there is no single answer. The best source from which to draw meaningful conclusions about gene expression depends on the specific question being asked. And generalizing from one tissue to another inevitably involves appropriate caveats that must temper interpretation.
(read more…)
Related Posts
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
RNA sequencing helps predict stem cell transplant benefit in pediatric AML
Protein ‘switch’ determines whether liposarcoma cells will become aggressive
Precursor tRNAs sense temperature changes: heat stress-induced capped pre-tRNAs suppress protein synthesis
Ketamine increases neuroplasticity in female mice but not in males
Somatic mutations linked to vascular damage in progeria
Scientists map dormant cancer cells’ hideouts, opening new targets for treatment
Soluble signals released by neighboring cells direct how the human kidney is built
Genetics influence how cancer arises – and how it evolves
RNA-based testing uncovers extraordinary diversity in mutations driving lung cancer
Study offers new insights into why ex-smokers remain at elevated risk of lung disease
Learning the grammar of gene regulation
New findings could transform new treatment for rare brain tumor astroblastoma
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