Studies attempting to functionally interpret complex-disease susceptibility loci by GWAS and eQTL integration have predominantly employed microarrays to quantify gene-expression. RNA-Seq has the potential to discover a more comprehensive set of eQTLs and illuminate the underlying molecular consequence. Researchers from ...

Circular RNAs (circRNAs) belong to a recently re-discovered species of RNA that emerge during RNA maturation through a process called back-splicing. A downstream 5’ splice site is linked to an upstream 3’ splice site to form a circular transcript instead ...

University of Colorado – School of Medicine Biochemistry and Molecular Genetics Bioinformatics Fellows for the RNA Bioscience Initiative Position – Research Associate Posting # –  04509 The newly formed RNA Bioscience Initiative at the University of Colorado School of Medicine ...

Short-read sequencing has enabled the de novo assembly of several individual human genomes, but with inherent limitations in characterizing repeat elements. Now, an international team led by researchers at USC have sequenced a Chinese individual HX1 by single-molecule real-time (SMRT) ...

Improvements in maize breeding are required to feed a growing population and will depend on a more complete understanding of global gene expression in the plant. In a new publication from Cold Spring Harbor Laboratory (CSHL), scientists produced the largest ...

Sun, Apr 17, 1:00 – 5:00 PM 84/24 – A discovery on splicing variant patterns of leucine-tRNA synthetase gene based on targeted RNA sequencing HyoJin Song1, Daeyoon Kim1, Hyejoo Park1, Hyun Sub Cheong2, Sunghoon Kim3, Youngil Koh4, Sung-Soo Yoon4. 1Seoul ...

RNA editing is one of the post- or co-transcriptional processes that can lead to amino acid substitutions in protein sequences, alternative pre-mRNA splicing, and changes in gene expression levels. Although several methods have been suggested to identify RNA editing sites, ...

from GenomeWeb by Andrew P. Han NEW YORK (GenomeWeb) – Scientists interested but not well versed in transcriptome profiling can now go to the Broad Institute for help. The Broad Technology Labs Specialized Services Facility offers automated services for high-throughput ...

Dysregulation of transcription is associated with the pathogenesis of cardiovascular diseases, including congenital heart diseases and heart failure. However, it remains unclear how transcription factors regulate transcription in the heart and which genes are associated with cardiovascular diseases in humans. ...

RNA measurements may yield less insight about gene expression than assumed 2,667 Views Upcoming RNA-Seq Workshops 1,652 Views RNA Bioinformatics – New RNA-Seq Protocols from Methods in Molecular Biology 1,544 Views Microarray analysis workhorse limma – now capable of differential ...