Post-doc position available – single-cell multi-omics analyses in a first-in-human gene therapy trial

Faculty of Medicine, Department of Laboratory Medicine, Lund University – Postdoc Scholarship

We are looking for a computational scientist with strong interest in medical research to conduct single cell multi-omics data analyses in a first-in-man clinical gene therapy trial.

The candidate will become an important part of a translational research program at Lund University and Skåne University hospital developing novel therapies for anemia. The postdoctoral training will entail developing and implementing a single-cell multi-omics based clinical monitoring protocol for a gene therapy drug entering clinical trials in 2023. The aim of this substudy is to describe the therapeutic mechanism of the gene therapy drug and establish a new standard for describing pharmacological properties of gene therapy drugs in general.

Qualifications required

  • Applicants will have a PhD degree in bioinformatics, computational biology, genomics, systems biology, or a related subject (the PhD degree is obtained after 2019-08-15).
  • Advanced knowledge of Python, R/Bioconductor, Linux/UNIX environment.
  • Demonstrated experience in analysis of genome scale biological datasets, such as bulk RNA-seq, ATAC-seq, CUT&Tag, gene expression meta-analysis, and/or analysis of regulatory elements in the genome is required.
  • Proficiency in analysis of single cell datasets: single cell RNA-seq, single cell ATAC-seq, and single cell multi-omics analysis of gene expression and chromatin accessibility is a strong merit.
  • Strong publication record in peer-reviewed journals is important; the applicant will be expected to have an active role in study design and manuscript writing.
  • Excellent personal initiative and communication skills; should be able to work and communicate with colleagues in the ‘wet lab’ and train group members as and when required.

The applicant should not have been employed by Lund University within the last two years in order to be able to receive a scholarship.

Lund Stem Cell Center,  Lund University and the city of Lund:

Lund Stem Cell Center (SCC) at Lund University is a world-leading center for stem cell research with the mission of transferring basic science findings to the clinic in order to make a fundamental difference to improve human health. Established in 2003, the center now consists of 43 outstanding research groups, all performing fundamental, multidisciplinary research, mostly within the fields of neurology and hematology.

https://www.stemcellcenter.lu.se/

Lund University was founded in 1666 and is ranked among the world’s top 100 universities. The University in Lund has 42 000 students and 7 400 staff.  Situated in the greater Copenhagen area, Lund University is a pillar of Northern Europe´s most knowledge-intensive life-science cluster popularly called “Medicon Valley”.

https://mva.org/about-mva/Medicon-Valley/

The city of Lund is a vibrant city in southern Sweden with roots in medieval times while hobnobbing with modernity. Home to millennium old cathedral, the city prides itself for being a seat of advanced learning and technology. https://visitlund.se/en

Placement: Department of Laboratory medicin

Ref No: V 2022/1291

Duration: 2 years

Starting date: Flexible but preferably soon after

Last day for applying: 2019-08-15.

For further information about the project and position please contact:

Principal Investigator Johan Flygare; [email protected]

Other

Lund University encourages both men and women to apply for the position.

Information regarding post doc scholarships at Lund University

  • The scholarship amounts to 29,000 SEK/month and is normally paid three months in advance.
  • The scholarship is intended for the recipient’s own education and does not constitute compensation for work carried out for the University.
  • The scholarship is a grant and therefore not subjected to tax deduction.
  • The scholarship does not entitle the recipient to compensation in case of illness.
  • The scholarship does not constitute a pensionable income.
  • The scholarship does not entitle the recipient to vacation.
  • The scholarship does not include financial compensation for parental leave.
  • The scholarship does not entitle the recipient to allowance during travels in the line of duty.
  • The scholarship awarded is to be reviewed by the head of department every six months and the supervisor is to inform the head of department before each review of any significant circumstances.
  • Scholarships set up by Lund University for any individual may not run for a period of more than 24 months.
  • The scholarship follows the regulations established by the Vice-Chancellor of Lund University (June 27th 2013; Reg. No PE 2013/356).

Application

Application stating the reference number V 2022/1291 and containing a CV, a personal letter, proof of dissertation and relevant documents should be addressed to:

Principal Investigator Johan Flygare; [email protected]

Last day of application is 2022-08-15

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