Post-doc Position Available – Single Cell RNA-Seq

Postdoctoral Research Fellow – Genomics & Proteomics-POS000183

Date: Sep 25, 2015

Location: Boston, MA, US

Position Overview:

As a postdoctoral fellow in Genetics and Pharmacogenomics (GpGx) you will work with a highly collaborative team of scientists with expertise in genetics, molecular biology, bioinformatics, immuno-oncology, immunoassay development, and academia to conceive, design, plan and implement high throughput single cell RNA sequencing (scRNA-seq) platforms to profile the response of immune and cancer cells to immunotherapy in clinical samples.

The ideal candidate has a strong working understanding of molecular biology and next generation sequencing, including scRNA-seq sample preparation and data interpretation, and has research experience in a dynamic multidisciplinary environment. Responsibilities of this position include supporting the development and optimization of new scRNA-seq methods to apply to clinical samples in close collaboration with Computational Biology and Clinical groups.

Responsibilities include but are not limited to:

  • Leading the development and implementation of technology for high throughput assay for scRNA-seq for analysis of tumor immunotherapy response.
  • Collaborating with academic and commercial partners to develop and implement the best scRNA-seq technology for different types of clinical samples (blood, solid tumor, fine needle aspirates, core needle biopsy)
  • Explore diversity of expression programs among tumor and immune cells using both unsupervised and supervised approaches
  • Utilize integrative data analysis approaches to identify biomarkers, new targets, and specific cellular mechansims that drive response and resistance to immunotherapy


Education Minimum Requirement:

PhD with 3 years or less of postdoctoral experience or met all the requirements for a PhD by May 2016

Required Experience and Skills:

  • Experience in assay development and innovation
  • Experience in standard molecular biology techniques and an understanding of the practices and principals of NGS, including hands-on development and optimization of RNA-seq protocols
  • Experience with data analysis of RNA sequencing data
  • Ability to work independently, design experiments, interpret and track results, and utilize this information to enable assay development

Preferred Experience and Skills:

  • Strong history of publication in peer-reviewed journals
  • Experience with programming in R
  • Ability to analyze and transfer NGS data in a UNIX computing environment
  • Experience with proteomic assays
  • Experience with microfluidic and/or microwell devices
  • Experience operating high throughput lab automation and NGS-sequencers
  • Experience working with typical oncology specimens (e.g. FFPE, Blood, Bone Marrow)
  • An understanding of immunology/immuno-oncology, cell signalling, and tools for characterization of immune response to experimental and therapeutic perturbation

Our employees are the key to our company’s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

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