Putting transcriptomics in its place

from Nature Reviews Genetics by Darren J. Burgess

A recent focus of transcriptomics is to supplement gene expression data with spatial information on cellular or tissue context in order to obtain a greater understanding of physiological gene regulatory processes. A challenge has been to achieve high-throughput in both the comprehensiveness of transcripts and the number of cells analysed. Three new studies report methodological advances that facilitate high-throughput spatially resolved transcriptomics.

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1. Chen, K. H. et al. (2015) Spatially resolved, highly multiplexed RNA profiling in single cells. Science [abstract]
2. Satija, R. et al. (2015) Spatial reconstruction of single-cell gene expression data. Nature Biotech [abstract]
3. Achim, K. et al. (2015) High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin. Nature Biotech [abstract]

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