Reference genome sequence of the model plant Setaria

The genus Setaria includes natural and cultivated species that demonstrate a wide capacity for adaptation. A team led by researchers at the University of Georgia has generated a high-quality reference genome sequence for foxtail millet (Setaria italica). The ~400-Mb assembly covers ~80% of the genome and >95% of the gene space. The assembly was anchored to a 992-locus genetic map and was annotated by comparison with >1.3 million expressed sequence tag reads.

They produced more than 580 million RNA-Seq reads to facilitate expression analyses. They also sequenced Setaria viridis, the ancestral wild relative of S. italica, and identified regions of differential single-nucleotide polymorphism density, distribution of transposable elements, small RNA content, chromosomal rearrangement and segregation distortion.


  • Bennetzen JL et. al. (2012) Reference genome sequence of the model plant Setaria. Nat Biotechnol [Epub ahead of print]. [article]