Research Fellow Position Available – RNA Splicing

Requisition Number 15-0350
Post Date 8/11/2015
Title RESEARCH FELLOW
Department Ocular Genomics-Pierce
Shift Day
Hours Per Week 40
City Boston
State MA
Description The Ocular Genomics Institute at the Massachusetts Eye and Ear, Harvard Medical School is seeking a talented postdoctoral fellow to join our team to study how mutations in RNA splicing factors cause retinal degeneration. Mutations in genes that encode RNA splicing factors are common causes of the inherited retinal degeneration retinitis pigmentosa (RP), which in turn is an important cause of vision loss. Since RNA splicing is a ubiquitous process, it is not clear why mutations in genes that encode components of the spliceosome lead to retina-specific neurodegeneration. We are investigating the pathogenesis of RNA splicing factor retinal degeneration using a combination of cell-based and animal models of disease. This includes use of genome-edited human induced pluriopotent stem cell (hiPSC) – derived cells and RNA-seq analyses to test the hypothesis that aberrant splicing in retinal cells underlies these disorders. We are also working to develop gene therapy for one of the genetic forms of these disorders. The project is supported by a newly renewed R01 and private foundation funding.Interested candidates should send their CV, a cover letter, and contact information for 3 references to:
Dr. Eric A Pierce
Director, Ocular Genomics Institute
Mass Eye and Ear
243 Charles St
Boston, MA 02114
[email protected]Applications will be considered until the position is filled.
Requirements Qualified candidates should have a doctoral degree, strong molecular and cellular biologic skills, and be able to work independently as well as in a group environment. This position offers an excellent opportunity to learn and apply skills in genetics, RNA-Seq, bioinformatics, molecular biology, CRISPR/Cas9 genome editing, and hiPSC technology. Experience in one or more of these areas is preferred, but not required.

 

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